Protein profile

PA5261

alginate biosynthesis regulatory protein AlgR

Genome: NC_002516.2

Gene: PA5261 algR Structure source: AlphaFold UniProt P26275

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Amino acids 248

Annotations 18

Features 21

PDB binders 2

Druggability 0.669

Overview

Basic information about this protein and its source genome.

Accession: PA5261
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5261 algR
Status: annotated
Amino acids: 248
Structure source: AlphaFold

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000156 Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.669

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MNVLIVDDEPLARERLARLVGQLDGYRVLEPSASNGEEALTLIDSLKPDIVLLDIRMPGLDGLQVAARLCEREAPPAVIFCTAHDEFALEAFQVSAVGYLVKPVRSEDLAEALKKASRPNRVQLAALTKPPASGGSGPRSHISARTRKGIELIPLEEVIFFIADHKYVTLRHAQGEVLLDEPLKALEDEFGERFVRIHRNALVARERIERLQRTPLGHFQLYLKGLDGDALTVSRRHVAGVRRLMHQL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

18 GO

Gene Ontology (GO)

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0032993 A macromolecular complex containing both protein and DNA molecules.
GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
GO:0000156 Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:2000147 Any process that activates or increases the frequency, rate or extent of cell motility.
GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GO:1900192 Any process that activates or increases the frequency, rate or extent of single-species biofilm formation.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:1901031 Any process that modulates the frequency, rate or extent of response to reactive oxygen species.
GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
1	122	SUPERFAMILY	SSF52172	CheY-like
1	122	InterPro	IPR011006	CheY-like superfamily
3	121	CDD	cd17532	REC_LytTR_AlgR-like
138	247	Gene3D	G3DSA:2.40.50.1020	-
148	246	SMART	SM00850	LytTR_3
148	246	InterPro	IPR007492	LytTR DNA-binding domain
1	125	Gene3D	G3DSA:3.40.50.2300	-
139	247	FunFam	G3DSA:2.40.50.1020:FF:000002	DNA-binding response regulator AlgR
149	245	Pfam	PF04397	LytTr DNA-binding domain
149	245	InterPro	IPR007492	LytTR DNA-binding domain
1	129	FunFam	G3DSA:3.40.50.2300:FF:000134	Autolysin response regulator LytR
142	247	ProSiteProfiles	PS50930	LytTR-type HTH domain profile.
142	247	InterPro	IPR007492	LytTR DNA-binding domain
3	113	Pfam	PF00072	Response regulator receiver domain
3	113	InterPro	IPR001789	Signal transduction response regulator, receiver domain
2	117	ProSiteProfiles	PS50110	Response regulatory domain profile.
2	117	InterPro	IPR001789	Signal transduction response regulator, receiver domain
1	113	SMART	SM00448	REC_2
1	113	InterPro	IPR001789	Signal transduction response regulator, receiver domain
1	221	PANTHER	PTHR48111	REGULATOR OF RPOS
1	221	InterPro	IPR039420	Transcriptional regulatory protein WalR-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5261	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.669

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
BEF	6EB7	A0A0H2UQ68	66.0 Da LogP 0.88 TPSA 0.0	✓ Ro5	✓ Clean	`[Be-](F)(F)F`
PHS	1NXP	A0A0H2UQ68	82.0 Da LogP -0.64 TPSA 57.5	✓ Ro5	✓ Clean	`OP(=O)O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.