Protein profile

PA5267

secreted protein Hcp

Genome: NC_002516.2

Gene: hcpC PA0263; hcpA PA1512; PA5267 hcpB Structure source: AlphaFold UniProt Q9HI36

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Amino acids 172

Annotations 1

Features 9

PDB binders 0

Druggability 0.47

Overview

Basic information about this protein and its source genome.

Accession: PA5267
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: hcpC PA0263; hcpA PA1512; PA5267 hcpB
Status: annotated
Amino acids: 172
Structure source: AlphaFold

GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.47

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
2	172	Gene3D	G3DSA:2.30.110.20	-
2	172	InterPro	IPR036624	Hcp1-like superfamily
1	163	PANTHER	PTHR34319	MAJOR EXPORTED PROTEIN
1	168	NCBIfam	TIGR03344	type VI secretion system tube protein TssD/Hcp
1	168	InterPro	IPR008514	Type VI secretion system effector Hcp
6	155	Pfam	PF05638	Type VI secretion system effector, Hcp
6	155	InterPro	IPR008514	Type VI secretion system effector Hcp
2	171	SUPERFAMILY	SSF141452	Hcp1-like
2	171	InterPro	IPR036624	Hcp1-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5267	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.47