Protein profile

PA5272

adenylate cyclase

Genome: NC_002516.2

Gene: cyaA PA5272 Structure source: AlphaFold UniProt Q9HTS8
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Amino acids 950
Annotations 2
Features 8
PDB binders 0
Druggability 0.553

Overview

Basic information about this protein and its source genome.

Accession
PA5272
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
cyaA PA5272
Status
annotated
Amino acids
950
Structure source
AlphaFold
GO
GO:0004016 Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. GO:0006171 The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.553
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004016 Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
  • GO:0006171 The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
19 861 PANTHER PTHR38760 ADENYLATE CYCLASE
19 861 InterPro IPR000274 Adenylate cyclase, class-I
21 217 Pfam PF12633 Adenylate cyclase NT domain
21 217 InterPro IPR024685 Adenylate cyclase class-I, N-terminal domain
16 931 PIRSF PIRSF001444 Adenylate_cycl
16 931 InterPro IPR000274 Adenylate cyclase, class-I
244 844 Pfam PF01295 Adenylate cyclase, class-I
244 844 InterPro IPR000274 Adenylate cyclase, class-I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5272
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.553
6 0.401
14 0.3