Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5274
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5274 rnk
Status: annotated
Amino acids: 134
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0070063 Binding to an RNA polymerase molecule or complex. GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
GO:0070063 Binding to an RNA polymerase molecule or complex.
GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
27	126	PIRSF	PIRSF006092	GreA_GreB
27	126	InterPro	IPR023459	Transcription elongation factor GreA/GreB family
1	30	PIRSF	PIRSF006092	GreA_GreB
1	30	InterPro	IPR023459	Transcription elongation factor GreA/GreB family
1	43	FunFam	G3DSA:1.10.286.20:FF:000002	Regulator of nucleoside diphosphate kinase
44	134	FunFam	G3DSA:3.10.50.30:FF:000002	Regulator of nucleoside diphosphate kinase
1	43	Gene3D	G3DSA:1.10.286.20	-
29	126	PANTHER	PTHR30437	TRANSCRIPTION ELONGATION FACTOR GREA
29	126	InterPro	IPR023459	Transcription elongation factor GreA/GreB family
45	134	Gene3D	G3DSA:3.10.50.30	-
45	134	InterPro	IPR036953	Transcription elongation factor GreA/GreB, C-terminal domain superfamily
48	125	SUPERFAMILY	SSF54534	FKBP-like
50	124	Pfam	PF01272	Transcription elongation factor, GreA/GreB, C-term
50	124	InterPro	IPR001437	Transcription elongation factor, GreA/GreB, C-terminal
4	43	Pfam	PF14760	Rnk N-terminus
4	43	InterPro	IPR029462	Regulator of nucleoside diphosphate kinase, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA5274 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5274	AlphaFold	—	—	full sequence	—	Viewing