Protein profile

PA5290

hypothetical protein

Genome: NC_002516.2

Gene: PA5290 Structure source: AlphaFold UniProt Q9HTR4
Export view
Amino acids 497
Annotations 4
Features 29
PDB binders 0
Druggability 0.76

Overview

Basic information about this protein and its source genome.

Accession
PA5290
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5290
Status
annotated
Amino acids
497
Structure source
AlphaFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0032508 OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.76
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSLAIVHSRAQVGVEAPCVSVEAHLANGLPSLTLVGLPETAVRESKDRVRSALLNAGFDFPARRITLNLAPADLPKDGGRFDLAIALGILAASGQLPGTALDGLECLGELALSGAIRPVRGVLPAALAARDARRVLVVPKENAEEASLASGLTVFAVDHLLEIAGHLSGQAPLPPYQARGLLRAPFPYPDLAEVQGQAAAKRALLVAAAGAHNLLLSGPPGTGKTLLASRLPGLLPALDEDEALEVAAIHSVASHVPLRHWPQRPFRQPHHSASAPALVGGGSRPQPGEITLAHQGVLFLDELPEFERKVLEVLREPLESGEIVIARANGRVRFPARFQLVAAMNPCPCGYLGDPSGRCRCTPEQVQRYRGKLSGPLLDRIDLHVSVLRESTSLQPGHGETATAEVSERVGAARQRQLARQGCANAHLDLQAMHRNCALAEADRRWLEAAGERLELSLRALHRILKVARTLADLERIDAIERRHLAEALQYRAMTST

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0032508 OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
21 142 Pfam PF13541 Subunit ChlI of Mg-chelatase
191 497 Gene3D G3DSA:3.40.50.300 -
191 497 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
286 390 ProSiteProfiles PS50051 MCM family domain profile.
286 390 InterPro IPR001208 MCM domain
6 492 NCBIfam TIGR00368 YifB family Mg chelatase-like AAA ATPase
6 492 InterPro IPR004482 Mg chelatase-related protein
210 391 SMART SM00382 AAA_5
210 391 InterPro IPR003593 AAA+ ATPase domain
190 390 Pfam PF01078 Magnesium chelatase, subunit ChlI
190 390 InterPro IPR000523 Magnesium chelatase ChlI-like, catalytic domain
187 492 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
187 492 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
402 492 Pfam PF13335 Magnesium chelatase, subunit ChlI C-terminal
402 492 InterPro IPR025158 Mg chelatase-related protein, C-terminal domain
340 352 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature
340 352 InterPro IPR001208 MCM domain
288 302 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature
288 302 InterPro IPR001208 MCM domain
209 224 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature
209 224 InterPro IPR001208 MCM domain
316 329 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature
316 329 InterPro IPR001208 MCM domain
13 168 Gene3D G3DSA:3.30.230.10 -
13 168 InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
19 491 PANTHER PTHR32039 MAGNESIUM-CHELATASE SUBUNIT CHLI
19 491 InterPro IPR045006 Magnesium-chelatase subunit ChlI-like
8 169 SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like
8 169 InterPro IPR020568 Ribosomal protein S5 domain 2-type fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5290
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.76
1 0.6