Protein profile

PA5292

phosphorylcholine phosphatase

Genome: NC_002516.2

Gene: PA5292 pchP Structure source: Experimental + AlphaFold UniProt Q9HTR2
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Amino acids 349
Annotations 4
Features 13
PDB binders 0
Druggability 0.548

Overview

Basic information about this protein and its source genome.

Accession
PA5292
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5292 pchP
Status
annotated
Amino acids
349
Structure source
Experimental + AlphaFold
EC
3.1.3.75
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.548
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
23 349 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 236 PANTHER PTHR43344 PHOSPHOSERINE PHOSPHATASE
27 221 SUPERFAMILY SSF56784 HAD-like
27 221 InterPro IPR036412 HAD-like superfamily
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
26 347 Gene3D G3DSA:3.40.50.1000 -
26 347 InterPro IPR023214 HAD superfamily
61 163 Gene3D G3DSA:1.20.1440.310 -
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4AS2
X-ray 2.12 Å A,B,C,D
93.7% 23-349
PDBe RCSB PDBj File
Viewing
PDB 4AS3
X-ray 2.40 Å A,B,C,D
93.7% 23-349
PDBe RCSB PDBj File
Loaded
AlphaFold PA5292
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.548

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.93 0.937
2 2.2 0.053
3 1.38 0.017
4 0.82 0.003