Protein profile

PA5298

xanthine phosphoribosyltransferase

Genome: NC_002516.2

Gene: xpt PA5298 Structure source: AlphaFold UniProt Q9HTQ6
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Amino acids 190
Annotations 8
Features 14
PDB binders 6
Druggability 0.667

Overview

Basic information about this protein and its source genome.

Accession
PA5298
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
xpt PA5298
Status
annotated
Amino acids
190
Structure source
AlphaFold
EC
2.4.2.22
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000310 Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0006166 Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. GO:0046110 The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. GO:0032265 Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis. GO:0016763 Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.667
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDILKDKIRSEGIVLSEHVLKVDAFLNHQIDPQLMQQVGHAFATRFRDQGITKIVTIEASGIAPAVMAGLELGVPVIFARKYQSLTLKDNLYISKVFSFTKQTESTIAISAKHLNAHDHVLVIDDFLANGHAAKALIDLIGQAGASIAGLGIVIEKSFQDGRALLESEGYRVESLARVKSLAGGQVEFLD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0000310 Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.
  • GO:0006166 Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.
  • GO:0046110 The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
  • GO:0032265 Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis.
  • GO:0016763 Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).
  • GO:0043101 Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
38 176 CDD cd06223 PRTases_typeI
38 176 InterPro IPR000836 Phosphoribosyltransferase domain
1 188 SUPERFAMILY SSF53271 PRTase-like
1 188 InterPro IPR029057 Phosphoribosyltransferase-like
3 188 Gene3D G3DSA:3.40.50.2020 -
3 188 InterPro IPR029057 Phosphoribosyltransferase-like
3 188 PANTHER PTHR43864 HYPOXANTHINE/GUANINE PHOSPHORIBOSYLTRANSFERASE
32 156 Pfam PF00156 Phosphoribosyl transferase domain
32 156 InterPro IPR000836 Phosphoribosyltransferase domain
1 188 NCBIfam TIGR01744 xanthine phosphoribosyltransferase
1 188 InterPro IPR010079 Xanthine phosphoribosyltransferase
3 188 FunFam G3DSA:3.40.50.2020:FF:000027 Xanthine phosphoribosyltransferase
1 189 Hamap MF_01184 Xanthine phosphoribosyltransferase [xpt].
1 189 InterPro IPR010079 Xanthine phosphoribosyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5298
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.667

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
5GP
2FXV
P42085 363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
9DA
1L1Q
Q967M2 134.1 Da LogP 0.54 TPSA 67.6 ✓ Ro5 ✓ Clean c1c[nH]c2c1ncnc2N
ADE
5YW5
Q5NII9 135.1 Da LogP -0.06 TPSA 80.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)c(ncn2)N
G4P
1Y0B
P42085 603.2 Da LogP -2.22 TPSA 345.6 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…
PCP
1P4A
P37551 388.1 Da LogP -1.57 TPSA 220.5 1 viol. ✓ Clean C1[C@@H]([C@H]([C@H]([C@H]1O[P@](=O)(O)OP(=O)(O…
PRP
5Y07
Q66DQ2 390.1 Da LogP -2.23 TPSA 229.7 1 viol. ✓ Clean C([C@@H]1[C@H]([C@H]([C@H](O1)O[P@@](=O)(O)OP(=…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.