Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5310
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5310
Status: annotated
Amino acids: 529
Structure source: AlphaFold

GO

GO:0030572 Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group. GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.63

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0030572 Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group.
GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
51	250	Gene3D	G3DSA:3.30.870.10	Endonuclease Chain A
311	482	Gene3D	G3DSA:3.30.870.10	Endonuclease Chain A
53	522	PANTHER	PTHR21248	CARDIOLIPIN SYNTHASE
301	523	CDD	cd09113	PLDc_ymdC_like_2
328	466	Pfam	PF13091	PLD-like domain
328	466	InterPro	IPR025202	Phospholipase D-like domain
80	231	Pfam	PF13091	PLD-like domain
80	231	InterPro	IPR025202	Phospholipase D-like domain
31	529	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
172	199	SMART	SM00155	pld_4
172	199	InterPro	IPR001736	Phospholipase D/Transphosphatidylase
417	444	SMART	SM00155	pld_4
417	444	InterPro	IPR001736	Phospholipase D/Transphosphatidylase
172	199	ProSiteProfiles	PS50035	Phospholipase D phosphodiesterase active site profile.
1	29	SignalP_EUK	SignalP-noTM	SignalP-noTM
17	25	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
284	508	SUPERFAMILY	SSF56024	Phospholipase D/nuclease
67	232	CDD	cd09111	PLDc_ymdC_like_1
1	16	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
26	30	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	30	Phobius	SIGNAL_PEPTIDE	Signal peptide region
50	251	SUPERFAMILY	SSF56024	Phospholipase D/nuclease
417	444	ProSiteProfiles	PS50035	Phospholipase D phosphodiesterase active site profile.
1	39	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	28	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5310	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.63
5				0.276

PA5310