Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5325
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5325
Status: annotated
Amino acids: 316
Structure source: AlphaFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071396 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. GO:0051872 The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.728

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MNPIRPHRPLRLAACVTLAVSCCTHASEGGVDNIGPGTDGFFTLPLDVDNLPDHMFAFNVYYNHYEARKLNISSFGGKVSDVKISSDAIIPRLDYLSPLRIFGGRLGGYIAQPYLRQRVAAFGLSDERESMGDTTFAPIILWDMGKDLTLAAAVEVTVPTGKYDAERLANTSNNFYTYKPLFSFTWLPTERTELSLKATYSFNMENHDTDYRSGQIFHFDYSASYRVTDNLRLGLNGYYLKQTTDDKQNGETVRVFGFGEEVDDGVRGQVFAIGPAVHLTFLKYASAEIRWAKEFDVENRPEGDMLWAKLTIPFEL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0071396 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
GO:0051872 The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
12	22	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	22	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
1	11	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
76	310	Pfam	PF13557	Putative MetA-pathway of phenol degradation
76	310	InterPro	IPR025737	MetA-pathway of phenol degradation, putative
27	316	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	26	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	26	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
1	26	Phobius	SIGNAL_PEPTIDE	Signal peptide region
23	26	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5325	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.728
6				0.711

PA5325