Protein profile

PA5328

mono-heme cytochrome C

Genome: NC_002516.2

Gene: PA5328 Structure source: AlphaFold UniProt Q9HTM7
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Amino acids 129
Annotations 5
Features 25
PDB binders 0
Druggability 0.769

Overview

Basic information about this protein and its source genome.

Accession
PA5328
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5328
Status
annotated
Amino acids
129
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506 Binding to an iron (Fe) ion. GO:0051872 The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.769
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0051872 The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
50 127 Gene3D G3DSA:1.10.760.10 -
50 127 InterPro IPR036909 Cytochrome c-like domain superfamily
1 33 SignalP_EUK SignalP-noTM SignalP-noTM
49 126 FunFam G3DSA:1.10.760.10:FF:000029 Cytochrome c5
1 30 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 40 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
41 129 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
113 124 PRINTS PR00607 Class IE cytochrome C signature
113 124 InterPro IPR002323 Cytochrome c, class IE
59 70 PRINTS PR00607 Class IE cytochrome C signature
59 70 InterPro IPR002323 Cytochrome c, class IE
70 80 PRINTS PR00607 Class IE cytochrome C signature
70 80 InterPro IPR002323 Cytochrome c, class IE
98 110 PRINTS PR00607 Class IE cytochrome C signature
98 110 InterPro IPR002323 Cytochrome c, class IE
52 123 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
52 123 InterPro IPR009056 Cytochrome c-like domain
1 40 Phobius SIGNAL_PEPTIDE Signal peptide region
31 40 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
54 124 SUPERFAMILY SSF46626 Cytochrome c
54 124 InterPro IPR036909 Cytochrome c-like domain superfamily
14 125 PANTHER PTHR40942 -
14 125 InterPro IPR002323 Cytochrome c, class IE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5328
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.769