Protein profile

PA5346

hypothetical protein

Genome: NC_002516.2

Gene: PA5346 Structure source: Experimental + AlphaFold UniProt Q9HTL2
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Amino acids 469
Annotations 2
Features 14
PDB binders 0
Druggability 0.797

Overview

Basic information about this protein and its source genome.

Accession
PA5346
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5346
Status
annotated
Amino acids
469
Structure source
Experimental + AlphaFold
GO
GO:0002161 The hydrolysis of an incorrectly aminoacylated tRNA. GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.797
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0002161 The hydrolysis of an incorrectly aminoacylated tRNA.
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
195 395 ProSiteProfiles PS51833 HD-related output (HDOD) domain profile.
195 395 InterPro IPR013976 Metal-dependent hydrolase HDOD
12 153 Gene3D G3DSA:3.90.960.10 -
12 153 InterPro IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily
172 456 PANTHER PTHR33525 -
30 142 Pfam PF04073 Aminoacyl-tRNA editing domain
30 142 InterPro IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain
195 395 Pfam PF08668 HDOD domain
1 466 PIRSF PIRSF036888 HDGYPm_UCP036888
1 466 InterPro IPR014627 Uncharacterised conserved protein UCP036888, signal transduction HD-GYP-like, PA5346 type
157 465 Gene3D G3DSA:1.10.3210.10 Hypothetical protein af1432
180 452 SUPERFAMILY SSF109604 HD-domain/PDEase-like
19 145 SUPERFAMILY SSF55826 YbaK/ProRS associated domain
19 145 InterPro IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9QZK
X-ray 3.16 Å A,B,C,D
97.4% 10-466
PDBe RCSB PDBj File
Viewing
AlphaFold PA5346
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.797
4 0.573

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.16 0.599
2 3.15 0.107
3 2.29 0.058
4 1.45 0.019
5 1.27 0.013