Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5348
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: hupA PA5348
Status: annotated
Amino acids: 90
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.892

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
1	90	SUPERFAMILY	SSF47729	IHF-like DNA-binding proteins
1	90	InterPro	IPR010992	Integration host factor (IHF)-like DNA-binding domain superfamily
46	65	ProSitePatterns	PS00045	Bacterial histone-like DNA-binding proteins signature.
46	65	InterPro	IPR020816	Histone-like DNA-binding protein, conserved site
1	90	SMART	SM00411	bhlneu
1	90	InterPro	IPR000119	Histone-like DNA-binding protein
1	90	FunFam	G3DSA:4.10.520.10:FF:000004	HU family DNA-binding protein
3	87	CDD	cd13831	HU
1	90	Gene3D	G3DSA:4.10.520.10	-
1	90	Pfam	PF00216	Bacterial DNA-binding protein
40	55	PRINTS	PR01727	Prokaryotic integration host factor signature
40	55	InterPro	IPR000119	Histone-like DNA-binding protein
74	88	PRINTS	PR01727	Prokaryotic integration host factor signature
74	88	InterPro	IPR000119	Histone-like DNA-binding protein
58	71	PRINTS	PR01727	Prokaryotic integration host factor signature
58	71	InterPro	IPR000119	Histone-like DNA-binding protein
11	38	Coils	Coil	Coil
2	89	PANTHER	PTHR33175	DNA-BINDING PROTEIN HU
2	89	InterPro	IPR000119	Histone-like DNA-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5348	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.892

PA5348