Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5356
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: glcC PA5356
Status: annotated
Amino acids: 251
Structure source: AlphaFold

GO

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.497

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
94	225	SMART	SM00895	FCD_2
94	225	InterPro	IPR011711	GntR, C-terminal
29	43	PRINTS	PR00035	GntR bacterial regulatory protein HTH signature
29	43	InterPro	IPR000524	Transcription regulator HTH, GntR
43	59	PRINTS	PR00035	GntR bacterial regulatory protein HTH signature
43	59	InterPro	IPR000524	Transcription regulator HTH, GntR
3	73	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
3	73	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
4	72	ProSiteProfiles	PS50949	GntR-type HTH domain profile.
4	72	InterPro	IPR000524	Transcription regulator HTH, GntR
216	246	Coils	Coil	Coil
91	232	SUPERFAMILY	SSF48008	GntR ligand-binding domain-like
91	232	InterPro	IPR008920	Transcription regulator FadR/GntR, C-terminal
1	75	Gene3D	G3DSA:1.10.10.10	-
1	75	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
7	69	Pfam	PF00392	Bacterial regulatory proteins, gntR family
7	69	InterPro	IPR000524	Transcription regulator HTH, GntR
6	70	CDD	cd07377	WHTH_GntR
6	70	InterPro	IPR000524	Transcription regulator HTH, GntR
10	69	SMART	SM00345	gntr3
10	69	InterPro	IPR000524	Transcription regulator HTH, GntR
3	236	PANTHER	PTHR43537	TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
94	224	Pfam	PF07729	FCD domain
94	224	InterPro	IPR011711	GntR, C-terminal
93	233	Gene3D	G3DSA:1.20.120.530	-
93	233	InterPro	IPR008920	Transcription regulator FadR/GntR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5356	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.286

PA5356