Protein profile

PA5368

phosphate ABC transporter permease

Genome: NC_002516.2

Gene: pstC PA5368 Structure source: AlphaFold UniProt G3XD02 UniProt Q51544
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Amino acids 677
Annotations 4
Features 37
PDB binders 0
Druggability 0.892

Overview

Basic information about this protein and its source genome.

Accession
PA5368
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pstC PA5368
Status
annotated
Amino acids
677
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.892
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

37 records
Show feature table
Start End DB Term Name
477 498 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
368 444 SUPERFAMILY SSF161098 MetI-like
368 444 InterPro IPR035906 MetI-like superfamily
573 593 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
443 465 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
466 476 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
381 403 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
642 663 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
440 444 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
443 673 Gene3D G3DSA:1.10.3720.10 -
443 673 InterPro IPR035906 MetI-like superfamily
499 527 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
528 552 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
415 439 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
553 572 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
576 598 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
477 499 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 677 PANTHER PTHR42727 PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN
394 672 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
394 672 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 380 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
446 662 SUPERFAMILY SSF161098 MetI-like
446 662 InterPro IPR035906 MetI-like superfamily
375 663 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
375 663 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
381 403 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 309 SUPERFAMILY SSF50978 WD40 repeat-like
22 309 InterPro IPR036322 WD40-repeat-containing domain superfamily
416 438 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
513 611 CDD cd06261 TM_PBP2
513 611 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
445 465 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
644 666 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
594 641 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
404 414 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
528 547 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
664 677 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5368
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.892
9 0.558
4 0.498
13 0.479