Protein profile

PA5370

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA5370 Structure source: AlphaFold UniProt Q9HTJ4
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Amino acids 438
Annotations 5
Features 49
PDB binders 0
Druggability 0.807

Overview

Basic information about this protein and its source genome.

Accession
PA5370
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5370
Status
annotated
Amino acids
438
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.807
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015293 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
100 122 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
281 303 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
120 124 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
149 159 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
377 399 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 237 FunFam G3DSA:1.20.1250.20:FF:000001 Dicarboxylate MFS transporter
195 214 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
283 304 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
332 342 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
343 366 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
367 377 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
249 271 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
404 426 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
87 97 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
400 404 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
125 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
65 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 46 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
127 149 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 22 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
47 65 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
249 271 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
311 331 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 428 PANTHER PTHR43528 ALPHA-KETOGLUTARATE PERMEASE
7 426 SUPERFAMILY SSF103473 MFS general substrate transporter
7 426 InterPro IPR036259 MFS transporter superfamily
98 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
22 429 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
22 429 InterPro IPR020846 Major facilitator superfamily domain
27 237 Pfam PF00083 Sugar (and other) transporter
27 237 InterPro IPR005828 Major facilitator, sugar transporter-like
160 183 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
158 180 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
378 399 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
19 244 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
19 244 InterPro IPR036259 MFS transporter superfamily
427 438 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
272 282 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
195 214 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
342 364 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
310 332 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
245 435 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
245 435 InterPro IPR036259 MFS transporter superfamily
405 426 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
184 194 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
305 310 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
215 248 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5370
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.807
5 0.241