Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5379
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5379 sdaB
Status: annotated
Amino acids: 458
Structure source: AlphaFold

EC

4.3.1.17

GO

GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0031459 Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). GO:0003941 Catalysis of the reaction: L-serine = pyruvate + NH4+. GO:0046872 Binding to a metal ion. GO:0009063 The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0006094 The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.328

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

4.3.1.17

Gene Ontology (GO)

6

GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0031459 Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).
GO:0003941 Catalysis of the reaction: L-serine = pyruvate + NH4+.
GO:0046872 Binding to a metal ion.
GO:0009063 The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
GO:0006094 The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
11	158	FunFam	G3DSA:3.30.1330.90:FF:000001	L-serine ammonia-lyase 1
2	454	PANTHER	PTHR30182	L-SERINE DEHYDRATASE
17	154	SUPERFAMILY	SSF143548	Serine metabolism enzymes domain
17	154	InterPro	IPR029009	Allosteric substrate binding domain superfamily
11	158	Gene3D	G3DSA:3.30.1330.90	-
11	158	InterPro	IPR029009	Allosteric substrate binding domain superfamily
3	454	NCBIfam	TIGR00720	L-serine ammonia-lyase
3	454	InterPro	IPR004644	Iron-sulphur-dependent L-serine dehydratase single chain form
186	452	Pfam	PF03313	Serine dehydratase alpha chain
186	452	InterPro	IPR005130	Serine dehydratase-like, alpha subunit
4	154	Pfam	PF03315	Serine dehydratase beta chain
4	154	InterPro	IPR005131	Serine dehydratase beta chain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5379	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.319

PA5379