Protein profile

PA5433

hypothetical protein

Genome: NC_002516.2

Gene: PA5433 Structure source: AlphaFold UniProt Q9HTD3
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Amino acids 224
Annotations 4
Features 9
PDB binders 0
Druggability 0.751

Overview

Basic information about this protein and its source genome.

Accession
PA5433
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5433
Status
annotated
Amino acids
224
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990189 Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. GO:0008999 Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein]. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.751
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MREPLNWRPVATPPHAPLDGRFVKLEPLDPQRHGDDLWDALQGPGADPLLWEYLAYGPFAERPAFDAWLAGQAASRDPLFFAVRERRTQRAVGLLSYLRITPKDGVIEIGHIAFGAPMQRTPGSTEAVYLLAELALGRLGYRRLEWKCNAGNARSLRAAERLGFTYEGTFRQHMVVKQRNRDTAWFSLLDSEWPARRAAFERWLDPSNFDAEGRQRQTLEALRD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:1990189 Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein].
  • GO:0008999 Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
23 182 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
23 182 InterPro IPR000182 GNAT domain
6 224 FunFam G3DSA:3.40.630.30:FF:000047 Acetyltransferase, GNAT family
15 189 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
15 189 InterPro IPR016181 Acyl-CoA N-acyltransferase
5 224 Gene3D G3DSA:3.40.630.30 -
4 199 PANTHER PTHR43441 RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE
46 165 Pfam PF13302 Acetyltransferase (GNAT) domain
46 165 InterPro IPR000182 GNAT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5433
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.751