Protein profile

PA5434

tryptophan permease

Genome: NC_002516.2

Gene: PA5434 mtr Structure source: AlphaFold UniProt Q9HTD2
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Amino acids 417
Annotations 5
Features 60
PDB binders 0
Druggability 0.758

Overview

Basic information about this protein and its source genome.

Accession
PA5434
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5434 mtr
Status
annotated
Amino acids
417
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015173 Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0003333 The process in which an amino acid is transported across a membrane. GO:0015801 The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.758
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSSSPAQTPSRRPSLLGGSMIIAGTAVGAGMFSLPIAMSGIWFGWSVAVFLLTWFCMLLSGMMILEANLNYPVGSSFSTITRDLLGQGWNVVNGLSIAFVLYILTYAYISGGGSIIGYTLSSGLGVTLPEKLAGLLFALAVALVVWWSTRAVDRITTLMLGGMIITFGLSISGLLGRIQPAILFNSGEPDAVYWPYLLATLPFCLTSFGYHGNVPSLMKYYGKDPQRISRSLWIGTLIALAIYLLWQASTLGTIPREQFKGIIAGGSNVGTLVEYLHRITASDSLKALLTTFSNLAVASSFLGVTLGLFDYLADLCRFDDSHFGRFKTALLTFVPPTIGGLLFPNGFIYAIGFAGLAAAFWAVIVPALMARASRKRFGSPLFRAWGGTPAIVLVLLFGVANAVAHILASLHWLPEYR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015173 Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0003333 The process in which an amino acid is transported across a membrane.
  • GO:0015801 The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records
Show feature table
Start End DB Term Name
321 343 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
370 389 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
235 254 PRINTS PR00166 Aromatic amino acid permease signature
235 254 InterPro IPR013059 Tryptophan/tyrosine transporter
20 43 PRINTS PR00166 Aromatic amino acid permease signature
20 43 InterPro IPR013059 Tryptophan/tyrosine transporter
92 112 PRINTS PR00166 Aromatic amino acid permease signature
92 112 InterPro IPR013059 Tryptophan/tyrosine transporter
330 348 PRINTS PR00166 Aromatic amino acid permease signature
330 348 InterPro IPR013059 Tryptophan/tyrosine transporter
296 315 PRINTS PR00166 Aromatic amino acid permease signature
296 315 InterPro IPR013059 Tryptophan/tyrosine transporter
158 178 PRINTS PR00166 Aromatic amino acid permease signature
158 178 InterPro IPR013059 Tryptophan/tyrosine transporter
196 218 PRINTS PR00166 Aromatic amino acid permease signature
196 218 InterPro IPR013059 Tryptophan/tyrosine transporter
47 66 PRINTS PR00166 Aromatic amino acid permease signature
47 66 InterPro IPR013059 Tryptophan/tyrosine transporter
351 370 PRINTS PR00166 Aromatic amino acid permease signature
351 370 InterPro IPR013059 Tryptophan/tyrosine transporter
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
89 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
211 229 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 309 PIRSF PIRSF006060 AA_transporter
320 414 PIRSF PIRSF006060 AA_transporter
192 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
348 370 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 398 NCBIfam TIGR00837 aromatic amino acid transporter
17 398 InterPro IPR013059 Tryptophan/tyrosine transporter
9 413 Gene3D G3DSA:1.20.1740.10 Amino acid/polyamine transporter I
287 309 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 416 FunFam G3DSA:1.20.1740.10:FF:000019 Tryptophan permease TnaB
41 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
391 413 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
414 417 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
191 210 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
347 369 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
310 346 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
230 246 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 405 Pfam PF03222 Tryptophan/tyrosine permease family
12 405 InterPro IPR018227 Amino acid/polyamine transporter 2
10 416 PANTHER PTHR46997 LOW AFFINITY TRYPTOPHAN PERMEASE-RELATED
10 416 InterPro IPR013059 Tryptophan/tyrosine transporter
99 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
232 254 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 131 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
180 190 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
390 413 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 40 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
247 286 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
126 148 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
287 309 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 14 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
155 179 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
132 149 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
150 154 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5434
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.758
1 0.738