Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5440
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5440
Status: annotated
Amino acids: 464
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.748

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MTATTLRPELLCPAGTLKSMRYAFAYGADAVYAGQPRYSLRVRNNDFDHAQLAEGIAEAHALGKRFYVVVNIAPHNAKLKTFLRDLEPVVAMGPDALIMSDPGLIMLVRQHFPQMPIHLSVQANAVNWAAVQFWRQQGLTRVILSRELSLEEIEEIRQQVPDMELEVFVHGALCMAYSGRCLLSGYINRRDPNQGTCTNACRWEYKAVEGREDELGNVVAREPTLGRGAPTEQVFLLEEGNRPGEPMAAFEDEHGTYIMNSKDLRAVQHVERLARIGVHSLKIEGRTKSHYYVARTAQVYRQAIDDAAAGKPFDRGLMDTLESLAHRGYTEGFLRRHVHDEYQNYQHGHSLSERQQFVGELTGERRDGLAEVEVKNRFQRGDSVELMTPRGNLSLRVEDLRNAAGEAIEVAPGNGHVVYLALPEGLDLCYALLMRDLQPGQDTRQPQAERSGGCAGKGACGCAH

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
351	435	Gene3D	G3DSA:2.40.30.10	Translation factors
80	337	Pfam	PF01136	Peptidase family U32
80	337	InterPro	IPR001539	Peptidase U32
166	184	ProSitePatterns	PS01276	Peptidase family U32 signature.
166	184	InterPro	IPR001539	Peptidase U32
6	400	PANTHER	PTHR30217	PEPTIDASE U32 FAMILY
354	425	Pfam	PF16325	Peptidase family U32 C-terminal domain
354	425	InterPro	IPR032525	Peptidase family U32, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5440	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.748
6				0.395
4				0.382

PA5440