Protein profile

PA5448

glycosyltransferase WbpY

Genome: NC_002516.2

Gene: wbpY PA5448 Structure source: AlphaFold UniProt Q9HTB9
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Amino acids 375
Annotations 3
Features 10
PDB binders 6
Druggability 0.661

Overview

Basic information about this protein and its source genome.

Accession
PA5448
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
wbpY PA5448
Status
annotated
Amino acids
375
Structure source
AlphaFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.661
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MRIAVNARILQAPRTGIGHYLVELLGALQAHADFEFSLFHGWGWSGDLPAAALPGYSRLSPWLRNLPGAYRARRWLEQRRFDSGRPPVDLYHEPSLWPLDFDGPMLMTLHDLTHLHYPATQPAARLREIERRLARGMEKARLILTDSQAIADEAQAYFGLPRERFVVAPLGHAARFRPRDRESLREPLRAHGLVPRGYFLCVGTLEPRKNLSLALRAHGQLPAAVRQRFPLMIVGMPGWESRSLDDELRQALASGTVRLLGYLPDERVAELMSGARALVFPSIYEGFGLPVLEAMASGTPVLLTRLSAMPEVAGEAGSYIDPDDANGLSDMLVRMTEDTVYWECCREAGLRRAEQFSWKRCANLTAAAYRRAVEG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 371 PANTHER PTHR46401 GLYCOSYLTRANSFERASE WBBK-RELATED
198 335 Pfam PF00534 Glycosyl transferases group 1
198 335 InterPro IPR001296 Glycosyl transferase, family 1
11 373 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
186 356 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
2 367 CDD cd03809 GT4_MtfB-like
2 185 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
16 171 Pfam PF13439 Glycosyltransferase Family 4
16 171 InterPro IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain
185 372 FunFam G3DSA:3.40.50.2000:FF:000119 Glycosyl transferase group 1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5448
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.661
1 0.611

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FRU
3S27
P49040 180.2 Da LogP -3.22 TPSA 110.4 ✓ Ro5 ✓ Clean C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
GDD
2GEJ
A0QWG6 605.3 Da LogP -4.63 TPSA 331.7 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…
LIP
3C4V
Q8NTA6 258.1 Da LogP -4.98 TPSA 173.6 ✓ Ro5 ✓ Clean [C@H]1([C@@H](C([C@H]([C@@H](C1O)O)O)OP(=O)([O-…
MLA
3S27
P49040 104.1 Da LogP -0.45 TPSA 74.6 ✓ Ro5 ✓ Clean C(C(=O)O)C(=O)O
MLT
3MBO
Q81ST7 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O
U2F
2IW1
P25740 568.3 Da LogP -3.82 TPSA 276.8 3 viol. ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.