Protein profile

PA5449

glycosyltransferase WbpX

Genome: NC_002516.2

Gene: wbpX L4V69_36945 PAERUG_P19_London_7_VIM_2_05_10_00873 ALP65_01266 gtf1 PA5449 Structure source: AlphaFold UniProt O84908 UniProt G3XCU3
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Amino acids 460
Annotations 3
Features 9
PDB binders 0
Druggability 0.771

Overview

Basic information about this protein and its source genome.

Accession
PA5449
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
wbpX L4V69_36945 PAERUG_P19_London_7_VIM_2_05_10_00873 ALP65_01266 gtf1 PA5449
Status
annotated
Amino acids
460
Structure source
AlphaFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.771
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
260 416 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
1 103 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
268 415 Pfam PF00534 Glycosyl transferases group 1
268 415 InterPro IPR001296 Glycosyl transferase, family 1
125 460 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 439 CDD cd03809 GT4_MtfB-like
104 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 411 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
16 436 PANTHER PTHR46401 GLYCOSYLTRANSFERASE WBBK-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5449
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.757