Protein profile

PA5456

hypothetical protein

Genome: NC_002516.2

Gene: PA5456 Structure source: AlphaFold UniProt Q9HTB4
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Amino acids 433
Annotations 3
Features 4
PDB binders 0
Druggability 0.69

Overview

Basic information about this protein and its source genome.

Accession
PA5456
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5456
Status
annotated
Amino acids
433
Structure source
AlphaFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.69
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MLIIIHSETNKTTIRQNLGRPEYSYYFVLKEFRPLLEEIGQVVEVSDPDELVDRLYHDCRKRGEPCVFLSFSPPHRTPIHHACPTIPVFAWEFSTLPSETWHGEPRHDWRHVLRHSGRAITHSSFTVDVVRAAMGRDYPVLSVPAPVWDRFANRASQQAGRPEARDVRLRLDGLLVDSRQLDLAVHADPEPSAEVLALPDRAAKQVELSLDGVIYTSVFNPYDGRKNWQDMISAFCATFRDEPDATLVLKLTHHNVGEALADMLHHLYKNQSYRCRIVLIHGYLADPDYERLVEATSYVVNTSYGEGQCLPLMEFMSSGKPAVAPRNTAMIDYIDADNAFIVDSSEEATAWPHDPRAAYRTLRYITDWESLCRAYRASFEVARQEPERYARMSAHASASLERFCSRKLAVERLRRFFDEAAQGDPSALQSIPA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
215 347 Pfam PF13692 Glycosyl transferases group 1
16 420 PANTHER PTHR46656 PUTATIVE-RELATED
200 420 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
82 421 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5456
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.69