Protein profile

PA5465

hypothetical protein

Genome: NC_002516.2

Gene: PA5465 Structure source: AlphaFold UniProt Q9HTA5

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Amino acids 139

Annotations 2

Features 8

PDB binders 0

Druggability 0.407

Overview

Basic information about this protein and its source genome.

Accession: PA5465
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5465
Status: annotated
Amino acids: 139
Structure source: AlphaFold

GO:0016846 Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 39.241
Human E-value: 6.02e-06
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.407

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0016846 Catalysis of the elimination of hydrogen sulfide or substituted H2S.
GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
5	112	ProSiteProfiles	PS51891	CENP-V/GFA domain profile.
5	112	InterPro	IPR006913	CENP-V/GFA domain
1	128	Gene3D	G3DSA:3.90.1590.10	-
1	130	SUPERFAMILY	SSF51316	Mss4-like
1	130	InterPro	IPR011057	Mss4-like superfamily
27	113	Pfam	PF04828	Glutathione-dependent formaldehyde-activating enzyme
27	113	InterPro	IPR006913	CENP-V/GFA domain
5	129	PANTHER	PTHR33337	GFA DOMAIN-CONTAINING PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5465	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.407
2				0.403
3				0.348
1				0.243