Protein profile

PA5470

peptide chain release factor-like protein

Genome: NC_002516.2

Gene: PA5470 Structure source: AlphaFold UniProt Q9HTA0
Export view
Amino acids 204
Annotations 3
Features 10
PDB binders 1
Druggability 0.727

Overview

Basic information about this protein and its source genome.

Accession
PA5470
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5470
Status
annotated
Amino acids
204
Structure source
AlphaFold
GO
GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
51.724
Human E-value
8.03e-12
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.727
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MILLQLSAAQGPAECCLAVAKAFERLCLEAAQAGVEVEVIEEVAGERPRTWRSLLLGLRGTAAEALAERWCGGIQWICPSPYRARHARKNWFIGAERFAAPPASLEGEIRFETLRSSGPGGQHVNTTDSAVRATHLASGISVRVQSQRSQHANKRLAILLIARRLADQASSAADALRAERRRAHGRISRGAARRVFRGERFEPA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
115 131 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature.
115 131 InterPro IPR000352 Peptide chain release factor class I
106 191 PANTHER PTHR43804 LD18447P
2 201 NCBIfam TIGR03072 peptide chain release factor H
2 201 InterPro IPR017509 Putative peptide chain release factor H
3 196 SUPERFAMILY SSF75620 Release factor
3 196 InterPro IPR045853 Peptide chain release factor class I superfamily
69 173 Gene3D G3DSA:3.30.160.20 -
107 191 Pfam PF00472 RF-1 domain
107 191 InterPro IPR000352 Peptide chain release factor class I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5470
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.727
1 0.362

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records
Chemistry signal

Structural ligand evidence is available for this target.

Direct evidence 0 51 via homologs
Structural ligands 1 0 loaded crystals
Bioactive compounds 0 50 ZINC candidates
Drug-like & clean 47 4 PAINS alerts
Best available ligand signal
FME PDB via homolog 177.2 Da · LogP -0.06 · TPSA 66.4
FME PDB via homolog ZINC221146246 ZINC candidate · Tanimoto 0.781 ZINC4544549 ZINC candidate · Tanimoto 0.758 ZINC2116511 ZINC candidate · Tanimoto 0.686

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FME
5MDV
P07012 177.2 Da LogP -0.06 TPSA 66.4 ✓ Ro5 ✓ Clean CSCC[C@@H](C(=O)O)NC=O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.