Amino acids
582
Annotations
4
Features
44
PDB binders
0
Druggability
0.85
Overview
Basic information about this protein and its source genome.
- Accession
- PA5473
- Gene
- PA5473
- Status
- annotated
- Amino acids
- 582
- Structure source
- AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005436 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
GO:0044341 The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- CytoplasmicMembrane
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.85
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
4 GO
Gene Ontology (GO)
4- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
- GO:0005436 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
- GO:0044341 The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
Sequence Features
Domain/signature hits from InterPro and related databases.
44 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 104 | 121 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 330 | 534 | Gene3D | G3DSA:1.20.58.220 | Phosphate transport system protein phou homolog 2; domain 2 |
| 330 | 534 | InterPro | IPR038078 | PhoU-like domain superfamily |
| 1 | 102 | PANTHER | PTHR10010 | SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED |
| 1 | 102 | InterPro | IPR003841 | Sodium-dependent phosphate transport protein |
| 204 | 226 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 152 | 170 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 308 | NCBIfam | TIGR00704 | Na/Pi-cotransporter II-related protein |
| 1 | 308 | InterPro | IPR004633 | Na/Pi-cotransporter II-related/YqeW-like protein |
| 1 | 3 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 171 | 196 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 133 | 151 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 24 | 46 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 274 | 296 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 197 | 207 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 158 | 256 | Pfam | PF02690 | Na+/Pi-cotransporter |
| 158 | 256 | InterPro | IPR003841 | Sodium-dependent phosphate transport protein |
| 13 | 147 | Pfam | PF02690 | Na+/Pi-cotransporter |
| 13 | 147 | InterPro | IPR003841 | Sodium-dependent phosphate transport protein |
| 4 | 26 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 11 | 300 | NCBIfam | NF037997 | Na/Pi symporter |
| 175 | 197 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 239 | 261 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 122 | 132 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 227 | 237 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 67 | 521 | NCBIfam | TIGR01013 | sodium-dependent inorganic phosphate transporter |
| 67 | 521 | InterPro | IPR003841 | Sodium-dependent phosphate transport protein |
| 76 | 98 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 67 | 89 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 208 | 226 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 133 | 155 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 47 | 69 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 258 | 582 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 1 | 23 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 238 | 257 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 320 | 532 | SUPERFAMILY | SSF109755 | PhoU-like |
| 99 | 121 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 70 | 75 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 16 | 23 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 99 | 103 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 4 | 15 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 537 | 582 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 340 | 422 | Pfam | PF01895 | PhoU domain |
| 340 | 422 | InterPro | IPR026022 | PhoU domain |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA5473
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 12 | 0.85 | ||||||
| 1 | 0.441 | ||||||
| 7 | 0.433 |