Protein profile

PA5490

cytochrome C4

Genome: NC_002516.2

Gene: cc4 PA5490 Structure source: Experimental + AlphaFold UniProt P00106
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Amino acids 201
Annotations 5
Features 28
PDB binders 0
Druggability 0.801

Overview

Basic information about this protein and its source genome.

Accession
PA5490
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
cc4 PA5490
Status
annotated
Amino acids
201
Structure source
Experimental + AlphaFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506 Binding to an iron (Fe) ion. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.801
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
22 100 Gene3D G3DSA:1.10.760.10 -
22 100 InterPro IPR036909 Cytochrome c-like domain superfamily
1 31 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
109 201 ProSiteProfiles PS51007 Cytochrome c family profile.
109 201 InterPro IPR009056 Cytochrome c-like domain
13 99 SUPERFAMILY SSF46626 Cytochrome c
13 99 InterPro IPR036909 Cytochrome c-like domain superfamily
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 201 PIRSF PIRSF000005 Cytochrome_c4
1 201 InterPro IPR024167 Cytochrome c4-like
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 20 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
22 100 ProSiteProfiles PS51007 Cytochrome c family profile.
22 100 InterPro IPR009056 Cytochrome c-like domain
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
21 201 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 201 PANTHER PTHR33751 CBB3-TYPE CYTOCHROME C OXIDASE SUBUNIT FIXP
21 102 FunFam G3DSA:1.10.760.10:FF:000016 Cytochrome c4
103 201 Gene3D G3DSA:1.10.760.10 -
103 201 InterPro IPR036909 Cytochrome c-like domain superfamily
104 201 FunFam G3DSA:1.10.760.10:FF:000022 Cytochrome c4
26 100 Pfam PF00034 Cytochrome c
26 100 InterPro IPR009056 Cytochrome c-like domain
112 199 Pfam PF00034 Cytochrome c
112 199 InterPro IPR009056 Cytochrome c-like domain
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
105 200 SUPERFAMILY SSF46626 Cytochrome c
105 200 InterPro IPR036909 Cytochrome c-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6Q2U
X-ray 1.85 Å A
90.0% 21-201
PDBe RCSB PDBj File
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AlphaFold PA5490
AlphaFold — — full sequence — Loaded
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Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 65.32 0.99
2 1.3 0.014