Protein profile

PA5492

ribosome biogenesis GTP-binding protein YsxC

Genome: NC_002516.2

Gene: PA5492 engB Structure source: AlphaFold UniProt Q9HT81
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Amino acids 215
Annotations 4
Features 16
PDB binders 0
Druggability 0.845

Overview

Basic information about this protein and its source genome.

Accession
PA5492
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5492 engB
Status
annotated
Amino acids
215
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525 Binding to GTP, guanosine triphosphate. GO:0046872 Binding to a metal ion. GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.638
Human E-value
1.48e-18
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.845
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005525 Binding to GTP, guanosine triphosphate.
  • GO:0046872 Binding to a metal ion.
  • GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
12 208 PANTHER PTHR11649 MSS1/TRME-RELATED GTP-BINDING PROTEIN
33 150 Pfam PF01926 50S ribosome-binding GTPase
33 150 InterPro IPR006073 GTP binding domain
14 198 NCBIfam TIGR03598 ribosome biogenesis GTP-binding protein YihA/YsxC
14 198 InterPro IPR019987 GTP-binding protein, ribosome biogenesis, YsxC
22 202 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
22 202 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
19 202 Hamap MF_00321 Probable GTP-binding protein EngB [engB].
19 202 InterPro IPR019987 GTP-binding protein, ribosome biogenesis, YsxC
30 204 ProSiteProfiles PS51706 EngB-type guanine nucleotide-binding (G) domain profile.
30 204 InterPro IPR030393 EngB-type guanine nucleotide-binding (G) domain
33 202 CDD cd01876 YihA_EngB
33 202 InterPro IPR030393 EngB-type guanine nucleotide-binding (G) domain
6 211 Gene3D G3DSA:3.40.50.300 -
6 211 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
7 214 FunFam G3DSA:3.40.50.300:FF:000098 Probable GTP-binding protein EngB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5492
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.845
5 0.308