Protein profile

PA5495

homoserine kinase

Genome: NC_002516.2

Gene: thrB PA5495 Structure source: AlphaFold UniProt P29364
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Amino acids 316
Annotations 4
Features 13
PDB binders 0
Druggability 0.515

Overview

Basic information about this protein and its source genome.

Accession
PA5495
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
thrB PA5495
Status
annotated
Amino acids
316
Structure source
AlphaFold
EC
2.7.1.39
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004413 Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. GO:0009088 The chemical reactions and pathways resulting in the formation of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.515
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0004413 Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.
  • GO:0009088 The chemical reactions and pathways resulting in the formation of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 303 NCBIfam TIGR00938 homoserine kinase
1 303 InterPro IPR005280 Homoserine kinase, type II
1 316 Hamap MF_00301 Homoserine kinase [thrB].
1 316 InterPro IPR005280 Homoserine kinase, type II
28 255 Pfam PF01636 Phosphotransferase enzyme family
28 255 InterPro IPR002575 Aminoglycoside phosphotransferase
105 314 Gene3D G3DSA:3.90.1200.10 -
5 306 SUPERFAMILY SSF56112 Protein kinase-like (PK-like)
5 306 InterPro IPR011009 Protein kinase-like domain superfamily
1 101 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1
19 285 PANTHER PTHR21064 UNCHARACTERIZED
9 305 CDD cd05153 HomoserineK_II
9 305 InterPro IPR005280 Homoserine kinase, type II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5495
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.444
2 0.419