Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5499
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5499 np20
Status: annotated
Amino acids: 167
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0008270 Binding to a zinc ion (Zn). GO:0071294 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.511

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

11 GO

Gene Ontology (GO)

11

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:0008270 Binding to a zinc ion (Zn).
GO:0071294 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
GO:0006882 A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:1900376 Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process.
GO:0071579 Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
17	105	Gene3D	G3DSA:1.10.10.10	-
17	105	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
17	105	FunFam	G3DSA:1.10.10.10:FF:000137	Zinc uptake transcriptional repressor
106	166	Gene3D	G3DSA:3.30.1490.190	-
106	166	InterPro	IPR043135	Ferric-uptake regulator, C-terminal domain
29	159	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
29	159	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
43	158	CDD	cd07153	Fur_like
43	158	InterPro	IPR002481	Ferric-uptake regulator
106	164	FunFam	G3DSA:3.30.1490.190:FF:000007	Fur family transcriptional regulator
19	166	PANTHER	PTHR33202	ZINC UPTAKE REGULATION PROTEIN
19	166	InterPro	IPR002481	Ferric-uptake regulator
35	154	Pfam	PF01475	Ferric uptake regulator family
35	154	InterPro	IPR002481	Ferric-uptake regulator

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5499	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.511

PA5499