Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5504
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5504
Status: annotated
Amino acids: 225
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other. GO:1903810 The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.91

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.
GO:1903810 The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
49	59	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
90	113	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
196	215	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
40	224	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
40	224	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
85	89	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
154	176	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
25	48	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
196	215	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
14	222	Gene3D	G3DSA:1.10.3720.10	-
14	222	InterPro	IPR035906	MetI-like superfamily
94	116	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
154	176	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	24	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16	212	SUPERFAMILY	SSF161098	MetI-like
16	212	InterPro	IPR035906	MetI-like superfamily
114	153	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
25	47	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	225	FunFam	G3DSA:1.10.3720.10:FF:000002	D-methionine ABC transporter permease MetI
60	211	CDD	cd06261	TM_PBP2
60	211	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
3	224	PANTHER	PTHR30450	ABC TRANSPORTER PERMEASE
177	195	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
216	225	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
68	90	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	215	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
21	215	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
60	84	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5504	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.91
6				0.79

PA5504