Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5506
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5506
Status: annotated
Amino acids: 285
Structure source: AlphaFold

GO

GO:0097367 Binding to a carbohydrate derivative. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:1901135 The chemical reactions and pathways involving carbohydrate derivative. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.897

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0097367 Binding to a carbohydrate derivative.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
1	76	Gene3D	G3DSA:1.10.10.10	-
1	76	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
120	254	CDD	cd05013	SIS_RpiR
120	254	InterPro	IPR035472	RpiR-like, SIS domain
2	78	SUPERFAMILY	SSF46689	Homeodomain-like
2	78	InterPro	IPR009057	Homeobox-like domain superfamily
95	278	Gene3D	G3DSA:3.40.50.10490	-
5	72	Pfam	PF01418	Helix-turn-helix domain, rpiR family
5	72	InterPro	IPR000281	Helix-turn-helix protein RpiR
1	276	PANTHER	PTHR30514	GLUCOKINASE
1	276	InterPro	IPR047640	HTH-type transcriptional regulator RpiR-like
2	78	ProSiteProfiles	PS51071	RpiR-type HTH domain profile.
2	78	InterPro	IPR000281	Helix-turn-helix protein RpiR
135	253	Pfam	PF01380	SIS domain
135	253	InterPro	IPR001347	SIS domain
97	266	SUPERFAMILY	SSF53697	SIS domain
97	266	InterPro	IPR046348	SIS domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5506	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.897
4				0.267

PA5506