Protein profile

PA5523

aminotransferase

Genome: NC_002516.2

Gene: PA5523 Structure source: AlphaFold UniProt Q9HT50
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Amino acids 450
Annotations 3
Features 11
PDB binders 7
Druggability 0.563

Overview

Basic information about this protein and its source genome.

Accession
PA5523
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5523
Status
annotated
Amino acids
450
Structure source
AlphaFold
GO
GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.962
Human E-value
2.56e-20
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.563
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MAREQQRFLAQNPQSVALAERARRALFDGVPMHWMSDWSTPCPLFVARAHGARFHDVDGHAYVDFCLGDTGSMFGHSPAPIARALAEQGANGLTTMLPGEDAIVAGELLAQRFGLPFWQVATTATDANRFVLRWARAITGRKVVLVFDGCYHGTVDDTLVRCRDGRTVHRSGLLGQAHDLTQFSRAVPFNDLQALERALAGEDVAAVLCEPAMTNIGMVLPQPGFHQKLRELTRRHGTLLIIDETHTISTGPGGCTRAWKLEPDFITLGKPIAGGVPCSVYGCSAAMASAMQLARARASEQSEGHGHSGMGTTLSANALAMRCMRANLEEVMTDTAYAHMLPLAARLAEGFRRIIHKHGLAWSVTELGARSEFQFCPQPPRDGAAAEAAFHDSLQMALHLYLINRGILITPFHNMTLCCPDTREEDVDRLLSSLDEALGELLAIPGAREA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
  • GO:0008483 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
36 415 InterPro IPR005814 Aminotransferase class-III
13 431 Gene3D G3DSA:3.90.1150.10 Aspartate Aminotransferase, domain 1
13 431 InterPro IPR015422 Pyridoxal phosphate-dependent transferase, small domain
36 415 Pfam PF00202 Aminotransferase class-III
12 441 SUPERFAMILY SSF53383 PLP-dependent transferases
12 441 InterPro IPR015424 Pyridoxal phosphate-dependent transferase
18 438 CDD cd00610 OAT_like
18 438 InterPro IPR005814 Aminotransferase class-III
78 336 Gene3D G3DSA:3.40.640.10 -
78 336 InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major domain
3 439 PANTHER PTHR43713 GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5523
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.563
3 0.542
2 0.282

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AKG
2YKX
A3EYF7 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
BNZ
2YKY
A3EYF7 78.1 Da LogP 1.69 TPSA 0.0 ✓ Ro5 ✓ Clean c1ccccc1
IK2
2YKV
A3EYF7 322.2 Da LogP -0.19 TPSA 158.4 ✓ Ro5 ✓ Clean Cc1c(c(c(cn1)COP(=O)(O)O)CNOCC(=O)O)O
PLK
4AO4
A3EYF7 376.3 Da LogP 1.68 TPSA 149.2 ✓ Ro5 ✓ Clean Cc1c(c(c(cn1)COP(=O)(O)O)CN[C@H](CC(C)C)CC(=O)O…
PLR
6K8H
D1C218 233.2 Da LogP 1.01 TPSA 99.9 ✓ Ro5 ✓ Clean Cc1c(cnc(c1O)C)COP(=O)(O)O
PMP
3BS8
P30949 248.2 Da LogP 0.16 TPSA 125.9 ✓ Ro5 ✓ Clean Cc1c(c(c(cn1)COP(=O)(O)O)CN)O
SFE
2YKY
A3EYF7 165.2 Da LogP 1.16 TPSA 63.3 ✓ Ro5 ✓ Clean c1ccc(cc1)C(CC(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.