Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5531
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tonB1
Status: annotated
Amino acids: 342
Structure source: ColabFold

GO

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.578

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
170	180	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
170	180	InterPro	IPR003538	Gram-negative bacterial TonB protein
296	313	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
296	313	InterPro	IPR003538	Gram-negative bacterial TonB protein
256	277	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
256	277	InterPro	IPR003538	Gram-negative bacterial TonB protein
277	295	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
277	295	InterPro	IPR003538	Gram-negative bacterial TonB protein
74	340	PANTHER	PTHR33446	PROTEIN TONB-RELATED
261	337	Pfam	PF03544	Gram-negative bacterial TonB protein C-terminal
261	337	InterPro	IPR037682	TonB, C-terminal
262	338	NCBIfam	TIGR01352	TonB family C-terminal domain
262	338	InterPro	IPR006260	TonB/TolA, C-terminal
128	260	MobiDBLite	mobidb-lite	consensus disorder prediction
255	336	SUPERFAMILY	SSF74653	TolA/TonB C-terminal domain
1	39	MobiDBLite	mobidb-lite	consensus disorder prediction
1	86	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
255	334	Gene3D	G3DSA:3.30.2420.10	TonB
226	246	MobiDBLite	mobidb-lite	consensus disorder prediction
109	342	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
154	201	MobiDBLite	mobidb-lite	consensus disorder prediction
87	108	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold PA5531	ColabFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.578
3				0.482

PA5531