Protein profile

PA5535

hypothetical protein

Genome: NC_002516.2

Gene: PA5535 Structure source: AlphaFold UniProt Q9HT39
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Amino acids 400
Annotations 2
Features 14
PDB binders 0
Druggability 0.57

Overview

Basic information about this protein and its source genome.

Accession
PA5535
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5535
Status
annotated
Amino acids
400
Structure source
AlphaFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
39.13
Human E-value
1.82e-07
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.57
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
256 373 SMART SM00833 CobW_C_3
256 373 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
3 310 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
3 310 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
5 394 NCBIfam NF038288 zinc metallochaperone GTPase ZigA
256 373 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain
241 373 Gene3D G3DSA:3.30.1220.10 -
241 373 InterPro IPR036627 CobW-like, C-terminal domain superfamily
2 229 Gene3D G3DSA:3.40.50.300 -
2 229 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 397 PANTHER PTHR43603 COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527
6 226 CDD cd03112 CobW-like
6 210 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain
6 210 InterPro IPR003495 CobW/HypB/UreG, nucleotide-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5535
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.57
7 0.523
2 0.279