Protein profile

PA5539

GTP cyclohydrolase

Genome: NC_002516.2

Gene: folE2 PA5539 Structure source: AlphaFold UniProt Q9HT35
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Amino acids 298
Annotations 5
Features 7
PDB binders 0
Druggability 0.897

Overview

Basic information about this protein and its source genome.

Accession
PA5539
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
folE2 PA5539
Status
annotated
Amino acids
298
Structure source
AlphaFold
EC
3.5.4.16
GO
GO:0003933 Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. GO:0003934 Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. GO:0046654 The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. GO:0035998 OBSOLETE. The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.897
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0003933 Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.
  • GO:0003934 Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+.
  • GO:0046654 The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
  • GO:0035998 OBSOLETE. The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
6 294 Hamap MF_01527_B GTP cyclohydrolase FolE2 [folE2].
6 294 InterPro IPR022838 GTP cyclohydrolase FolE2
3 296 PANTHER PTHR36445 GTP CYCLOHYDROLASE MPTA
3 296 InterPro IPR003801 GTP cyclohydrolase FolE2/MptA
6 289 Pfam PF02649 Type I GTP cyclohydrolase folE2
6 289 InterPro IPR003801 GTP cyclohydrolase FolE2/MptA
4 293 Gene3D G3DSA:3.10.270.10 Urate Oxidase;

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5539
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.897
7 0.295