Protein profile

PA5544

hypothetical protein

Genome: NC_002516.2

Gene: PA5544 Structure source: AlphaFold UniProt Q9HT30
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Amino acids 674
Annotations 2
Features 58
PDB binders 0
Druggability 0.752

Overview

Basic information about this protein and its source genome.

Accession
PA5544
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5544
Status
annotated
Amino acids
674
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.752
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

58 records
Show feature table
Start End DB Term Name
588 598 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
100 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
661 674 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
292 314 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
112 592 Pfam PF06808 Tripartite ATP-independent periplasmic transporter, DctM component
112 592 InterPro IPR010656 TRAP C4-dicarboxylate transport system permease DctM subunit
486 504 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
623 633 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
568 590 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
338 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
170 192 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
568 587 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 71 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 17 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
341 358 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
490 512 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
557 567 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
319 337 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
405 427 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
43 65 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
519 541 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
46 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
299 318 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
181 202 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
363 385 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
276 293 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 123 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
634 660 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
124 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
90 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
72 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
429 447 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
203 275 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 673 PANTHER PTHR43849 BLL3936 PROTEIN
448 479 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
531 534 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
632 665 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
595 617 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
448 470 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
535 556 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
384 394 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
357 361 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
480 485 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
395 428 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
41 45 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 668 NCBIfam TIGR02123 TRAP transporter fused permease subunit
16 668 InterPro IPR011853 TRAP C4-dicarboxylate transport system permease, fused DctM-DctQ
142 180 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
362 383 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
599 622 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
510 530 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
505 509 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
72 90 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
294 298 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
124 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5544
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.363
6 0.265