Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5550
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: glmR PA5550
Status: annotated
Amino acids: 257
Structure source: AlphaFold

GO

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0098531 A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:2000147 Any process that activates or increases the frequency, rate or extent of cell motility. GO:0045724 Any process that activates or increases the frequency, rate or extent of the formation of a cilium. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.751

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0098531 A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:2000147 Any process that activates or increases the frequency, rate or extent of cell motility.
GO:0045724 Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0032885 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
42	60	PRINTS	PR00037	LacR bacterial regulatory protein HTH signature
42	60	InterPro	IPR001034	DeoR-type HTH domain
28	42	PRINTS	PR00037	LacR bacterial regulatory protein HTH signature
28	42	InterPro	IPR001034	DeoR-type HTH domain
10	62	SMART	SM00420	deor2
10	62	InterPro	IPR001034	DeoR-type HTH domain
75	232	FunFam	G3DSA:3.40.50.1360:FF:000006	Glucitol operon repressor
2	56	Gene3D	G3DSA:1.10.10.10	-
2	56	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
76	221	Gene3D	G3DSA:3.40.50.1360	-
77	234	SUPERFAMILY	SSF100950	NagB/RpiA/CoA transferase-like
77	234	InterPro	IPR037171	NagB/RpiA transferase-like
8	250	PANTHER	PTHR30363	HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED
10	61	Pfam	PF08220	DeoR-like helix-turn-helix domain
10	61	InterPro	IPR001034	DeoR-type HTH domain
73	234	SMART	SM01134	DeoRC_2
79	233	Pfam	PF00455	DeoR C terminal sensor domain
79	233	InterPro	IPR014036	DeoR C-terminal sensor domain
7	62	ProSiteProfiles	PS51000	DeoR-type HTH domain profile.
7	62	InterPro	IPR001034	DeoR-type HTH domain
8	65	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
8	65	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
10	44	ProSitePatterns	PS00894	DeoR-type HTH domain signature.
10	44	InterPro	IPR018356	Transcription regulator, HTH DeoR-type, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5550	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.751

PA5550