Protein profile

PA5562

chromosome partitioning protein

Genome: NC_002516.2

Gene: PA5562 spoOJ Structure source: AlphaFold UniProt Q9HT12
Export view
Amino acids 290
Annotations 5
Features 19
PDB binders 0
Druggability 0.841

Overview

Basic information about this protein and its source genome.

Accession
PA5562
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5562 spoOJ
Status
annotated
Amino acids
290
Structure source
AlphaFold
GO
GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0042802 Binding to an identical protein or proteins. GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0045881 Any process that activates or increases the frequency, rate or extent of sporulation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.841
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0042802 Binding to an identical protein or proteins.
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
  • GO:0045881 Any process that activates or increases the frequency, rate or extent of sporulation.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
36 132 CDD cd16393 SPO0J_N
38 127 Pfam PF02195 ParB/Sulfiredoxin domain
38 127 InterPro IPR003115 ParB/Sulfiredoxin
34 204 NCBIfam TIGR00180 ParB/RepB/Spo0J family partition protein
34 204 InterPro IPR004437 ParB/RepB/Spo0J partition protein
177 227 Pfam PF17762 HTH domain found in ParB protein
177 227 InterPro IPR041468 ParB/Spo0J, HTH domain
50 112 FunFam G3DSA:3.90.1530.30:FF:000001 Chromosome partitioning protein ParB
141 171 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
141 171 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
141 161 Coils Coil Coil
114 226 FunFam G3DSA:1.10.10.2830:FF:000001 Chromosome partitioning protein ParB
10 289 PANTHER PTHR33375 CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED
50 113 Gene3D G3DSA:3.90.1530.30 -
36 180 SUPERFAMILY SSF110849 ParB/Sulfiredoxin
36 180 InterPro IPR036086 ParB/Sulfiredoxin superfamily
37 127 SMART SM00470 ParB_7
37 127 InterPro IPR003115 ParB/Sulfiredoxin
114 226 Gene3D G3DSA:1.10.10.2830 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5562
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.841
5 0.33