Protein profile

PA5568

inner membrane protein translocase subunit YidC

Genome: NC_002516.2

Gene: yidC PA5568 Structure source: AlphaFold UniProt Q9HT06
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Amino acids 578
Annotations 5
Features 60
PDB binders 0
Druggability 0.723

Overview

Basic information about this protein and its source genome.

Accession
PA5568
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
yidC PA5568
Status
annotated
Amino acids
578
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane. GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
28.302
Human E-value
4.28e-11
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.723
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDIQRSILIVALAVVSYLLVLQWNKDYGQPELPAASASMNTTQGLPDTPSASGTSSDVPTAQSSAAGSEAADKPVAVSDKLIQVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDRPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAGRPLFRSAQSSYQLADGQNELVVDLSFSHDGVNYIKRFTFHRGLKADCSDKEKAQKKIECINENAYQVGVSYLIDNQSGKTWSGNLFAQLKRDGSADPSSTTATGVSTYLGAAVWTPDSPYKKISTKDMDKEQFKESVQGGWVAWLQHYFVTAWVPTKGEQHQVMTRKDGQGNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLKELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLIGNWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLGWITDLSVKDPFFILPIVMGGTMLIQQMLNPTPPDPMQAKVMKLMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYITRKIEAAAKTA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
  • GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records
Show feature table
Start End DB Term Name
390 569 NCBIfam TIGR03592 membrane protein insertase YidC
390 569 InterPro IPR028055 Membrane insertase YidC/Oxa/ALB, C-terminal
80 367 CDD cd19961 EcYidC-like_peri
80 367 InterPro IPR028053 Membrane insertase YidC, N-terminal
380 390 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 359 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 190 NCBIfam TIGR03593 membrane protein insertase, YidC/Oxa1 family, N-terminal domain
4 190 InterPro IPR028053 Membrane insertase YidC, N-terminal
208 389 NCBIfam TIGR03593 membrane protein insertase, YidC/Oxa1 family, N-terminal domain
208 389 InterPro IPR028053 Membrane insertase YidC, N-terminal
392 569 CDD cd20070 5TM_YidC_Alb3
392 569 InterPro IPR047196 Membrane insertase YidC/ALB, C-terminal
255 273 PRINTS PR00701 60kDa inner membrane protein signature
255 273 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
2 23 PRINTS PR00701 60kDa inner membrane protein signature
2 23 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
452 475 PRINTS PR00701 60kDa inner membrane protein signature
452 475 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
288 303 PRINTS PR00701 60kDa inner membrane protein signature
288 303 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
535 558 PRINTS PR00701 60kDa inner membrane protein signature
535 558 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
361 381 PRINTS PR00701 60kDa inner membrane protein signature
361 381 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
499 521 PRINTS PR00701 60kDa inner membrane protein signature
499 521 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
456 478 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
391 413 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
497 514 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
412 453 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78 371 Gene3D G3DSA:2.70.98.90 -
78 371 InterPro IPR038221 YidC, periplasmic domain superfamily
515 534 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
533 555 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
535 555 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
556 578 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
391 411 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 571 Hamap MF_01810 Membrane protein insertase YidC [yidC].
4 571 InterPro IPR019998 Membrane insertase YidC
478 496 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
360 379 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
34 67 MobiDBLite mobidb-lite consensus disorder prediction
368 570 PANTHER PTHR12428 OXA1
368 570 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
82 380 Pfam PF14849 YidC periplasmic domain
82 380 InterPro IPR028053 Membrane insertase YidC, N-terminal
34 70 MobiDBLite mobidb-lite consensus disorder prediction
454 477 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
505 520 PRINTS PR01900 YidC translocation/secretion protein signature
505 520 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
376 392 PRINTS PR01900 YidC translocation/secretion protein signature
376 392 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
524 548 PRINTS PR01900 YidC translocation/secretion protein signature
524 548 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
78 371 FunFam G3DSA:2.70.98.90:FF:000005 Membrane protein insertase YidC
6 23 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
391 569 Pfam PF02096 60Kd inner membrane protein
391 569 InterPro IPR028055 Membrane insertase YidC/Oxa/ALB, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5568
AlphaFold — — full sequence — Viewing
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.723
21 0.706
1 0.525