Protein profile

VK055_0058

glycosyl Hydrolase Family 88 family protein

Genome: KpATCC43816

Gene: AIK78686.1 Structure source: Experimental + ColabFold UniProt A6TB44
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Amino acids 379
Annotations 1
Features 8
PDB binders 0
Druggability 0.302

Overview

Basic information about this protein and its source genome.

Accession
VK055_0058
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78686.1
Status
annotated
Amino acids
379
Structure source
Experimental + ColabFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
30.303
Localization
Cytoplasmic
ColabFold pLDDT
97.78

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.302
Structure 3PMM
Pocket Pocket 9
P2Rank 0.883
Structure 3PMM
Pocket Pocket 1
ColabFold model
FPocket 0.247 · Pocket 8
P2Rank 0.921 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 82 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 379 Gene3D G3DSA:1.50.10.10 -
1 379 InterPro IPR012341 Six-hairpin glycosidase-like superfamily
25 376 PANTHER PTHR33886 UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)
33 376 SUPERFAMILY SSF48208 Six-hairpin glycosidases
33 376 InterPro IPR008928 Six-hairpin glycosidase superfamily
21 41 Coils Coil Coil
38 377 Pfam PF07470 Glycosyl Hydrolase Family 88
38 377 InterPro IPR010905 Glycosyl hydrolase, family 88

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3PMM
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold VK055_0058
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.302

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.77 0.883
2 3.7 0.141
3 1.42 0.018