Target Pathogen

#1

KEGG

Polyketide sugar unit biosynthesis

map00523

3 Reactions

4 Proteins

3 Chokepoints

100.0% Density

0 Connects to

Best target signal 1.144 mean 0.672

Open pathway map

VK055_3187 drug 0.99 · cent 0.021 VK055_1727 drug 0.75 · cent 0.000 VK055_2134 drug 0.18 · cent 0.026 VK055_3186 drug 0.16 · cent 0.026

#2

KEGG

Acarbose and validamycin biosynthesis

map00525

2 Reactions

3 Proteins

2 Chokepoints

100.0% Density

0 Connects to

Best target signal 1.144 mean 0.595

Open pathway map

VK055_3187 drug 0.99 · cent 0.021 VK055_2134 drug 0.18 · cent 0.026 VK055_3186 drug 0.16 · cent 0.026

#3

KEGG

Biosynthesis of vancomycin group antibiotics

map01055

1 Reactions

1 Proteins

1 Chokepoints

100.0% Density

0 Connects to

Best target signal 1.144 mean 1.144

Open pathway map

VK055_3187 drug 0.99 · cent 0.021

#4

KEGG

Benzoxazinoid biosynthesis

map00402

1 Reactions

2 Proteins

1 Chokepoints

100.0% Density

0 Connects to

Best target signal 1.105 mean 1.097

Open pathway map

VK055_1196 drug 0.95 · cent 0.104 VK055_1197 drug 0.93 · cent 0.104

#5

KEGG

Styrene degradation

map00643

3 Reactions

5 Proteins

3 Chokepoints

100.0% Density

0 Connects to

Best target signal 1.102 mean 0.839

Open pathway map

VK055_2005 drug 0.95 · cent 0.051 VK055_1046 drug 0.89 · cent 0.051 VK055_1167 drug 0.74 · cent 0.000 VK055_0134 drug 0.46 · cent 0.018 VK055_1586 drug 0.40 · cent 0.000

#6

KEGG

Zeatin biosynthesis

map00908

1 Reactions

1 Proteins

1 Chokepoints

100.0% Density

2 Connects to

Best target signal 1.09 mean 1.09

Open pathway map

VK055_2895 drug 0.94 · cent 0.005

#7

KEGG

Biosynthesis of siderophore group nonribosomal peptides

map01053

2 Reactions

3 Proteins

2 Chokepoints

100.0% Density

2 Connects to

Best target signal 1.043 mean 0.843

Open pathway map

VK055_4852 drug 0.89 · cent 0.056 VK055_1923 drug 0.78 · cent 0.010 VK055_5126 drug 0.41 · cent 0.056

#8

KEGG

Biosynthesis of various other secondary metabolites

map00997

1 Reactions

1 Proteins

1 Chokepoints

100.0% Density

0 Connects to

Best target signal 0.803 mean 0.803

Open pathway map

VK055_2181 drug 0.65 · cent 0.005

#9

KEGG

Atrazine degradation

map00791

1 Reactions

1 Proteins

1 Chokepoints

100.0% Density

1 Connects to

Best target signal 0.785 mean 0.785

Open pathway map

VK055_0697 drug 0.63 · cent 0.010

#10

KEGG

Polycyclic aromatic hydrocarbon degradation

map00624

1 Reactions

2 Proteins

1 Chokepoints

100.0% Density

0 Connects to

Best target signal 0.773 mean 0.732

Open pathway map

VK055_0530 drug 0.62 · cent 0.035 VK055_0529 drug 0.54 · cent 0.035

#11

KEGG

Folate biosynthesis

map00790

11 Reactions

12 Proteins

9 Chokepoints

81.8% Density

4 Connects to

Best target signal 1.081 mean 0.63

Open pathway map

VK055_4808 drug 0.93 · cent 0.005 VK055_4377 drug 0.69 · cent 0.000 VK055_0122 drug 0.82 · cent 0.006 VK055_1178 drug 0.65 · cent 0.024 VK055_4010 drug 0.52 · cent 0.019

#12

KEGG

Streptomycin biosynthesis

map00521

5 Reactions

6 Proteins

4 Chokepoints

80.0% Density

3 Connects to

Best target signal 1.144 mean 0.639

Open pathway map

VK055_3187 drug 0.99 · cent 0.021 VK055_1727 drug 0.75 · cent 0.000 VK055_4774 drug 0.66 · cent 0.000 VK055_2777 drug 0.34 · cent 0.000 VK055_2134 drug 0.18 · cent 0.026

#13

KEGG

Biosynthesis of various nucleotide sugars

map00541

19 Reactions

20 Proteins

15 Chokepoints

78.9% Density

10 Connects to

Best target signal 1.144 mean 0.637

Open pathway map

VK055_3187 drug 0.99 · cent 0.021 VK055_3625 drug 0.85 · cent 0.025 VK055_2330 drug 0.82 · cent 0.031 VK055_3185 drug 0.81 · cent 0.000 VK055_1727 drug 0.75 · cent 0.000

#14

KEGG

Ubiquinone and other terpenoid-quinone biosynthesis

map00130

8 Reactions

10 Proteins

6 Chokepoints

75.0% Density

8 Connects to

Best target signal 1.09 mean 0.794

Open pathway map

VK055_4855 drug 0.94 · cent 0.036 VK055_4852 drug 0.89 · cent 0.056 VK055_3030 drug 0.92 · cent 0.139 VK055_3046 drug 0.91 · cent 0.140 VK055_4853 drug 0.73 · cent 0.041

#15

KEGG

Terpenoid backbone biosynthesis

map00900

10 Reactions

12 Proteins

7 Chokepoints

70.0% Density

7 Connects to

Best target signal 1.14 mean 0.768

Open pathway map

VK055_2182 drug 0.98 · cent 0.122 VK055_2379 drug 0.96 · cent 0.050 VK055_3880 drug 0.90 · cent 0.002 VK055_2378 drug 0.86 · cent 0.035 VK055_3136 drug 0.84 · cent 0.118

#16

KEGG

Inositol phosphate metabolism

map00562

6 Reactions

8 Proteins

4 Chokepoints

66.7% Density

9 Connects to

Best target signal 1.021 mean 0.748

Open pathway map

VK055_2778 drug 0.87 · cent 0.010 VK055_1343 drug 0.87 · cent 0.304 VK055_3463 drug 0.77 · cent 0.304 VK055_2775 drug 0.59 · cent 0.005 VK055_2788 drug 0.54 · cent 0.321

#17

KEGG

Monobactam biosynthesis

map00261

3 Reactions

6 Proteins

2 Chokepoints

66.7% Density

2 Connects to

Best target signal 0.778 mean 0.658

Open pathway map

VK055_4402 drug 0.63 · cent 0.010 VK055_2572 drug 0.73 · cent 0.089 VK055_4699 drug 0.57 · cent 0.016 VK055_0038 drug 0.54 · cent 0.016 VK055_3062 drug 0.60 · cent 0.089

#18

KEGG

Thiamine metabolism

map00730

8 Reactions

10 Proteins

5 Chokepoints

62.5% Density

9 Connects to

Best target signal 1.14 mean 0.568

Open pathway map

VK055_2182 drug 0.98 · cent 0.122 VK055_3099 drug 0.71 · cent 0.031 VK055_4349 drug 0.60 · cent 0.192 VK055_0323 drug 0.51 · cent 0.192 VK055_2185 drug 0.37 · cent 0.026

#19

KEGG

Phenylalanine, tyrosine and tryptophan biosynthesis

map00400

16 Reactions

18 Proteins

10 Chokepoints

62.5% Density

13 Connects to

Best target signal 1.126 mean 0.718

Open pathway map

VK055_1195 drug 0.97 · cent 0.035 VK055_1196 drug 0.95 · cent 0.104 VK055_1197 drug 0.93 · cent 0.104 VK055_1768 drug 0.78 · cent 0.048 VK055_1194 drug 0.78 · cent 0.035

#20

KEGG

Peptidoglycan biosynthesis

map00550

13 Reactions

10 Proteins

8 Chokepoints

61.5% Density

6 Connects to

Best target signal 1.025 mean 0.688

Open pathway map

VK055_2476 drug 0.87 · cent 0.008 VK055_2477 drug 0.89 · cent 0.070 VK055_2483 drug 0.74 · cent 0.025 VK055_2378 drug 0.86 · cent 0.035 VK055_2481 drug 0.69 · cent 0.066

#21

KEGG

beta-Alanine metabolism

map00410

5 Reactions

5 Proteins

3 Chokepoints

60.0% Density

6 Connects to

Best target signal 1.137 mean 0.635

Open pathway map

VK055_1043 drug 0.99 · cent 0.025 VK055_2788 drug 0.54 · cent 0.321 VK055_2428 drug 0.43 · cent 0.046 VK055_0557 drug 0.49 · cent 0.034 VK055_2429 drug 0.23 · cent 0.021

#22

KEGG

Sulfur cycle

map01320

5 Reactions

8 Proteins

3 Chokepoints

60.0% Density

0 Connects to

Best target signal 1.086 mean 0.74

Open pathway map

VK055_4404 drug 0.93 · cent 0.015 VK055_4399 drug 0.80 · cent 0.041 VK055_4398 drug 0.92 · cent 0.077 VK055_4743 drug 0.90 · cent 0.064 VK055_4402 drug 0.63 · cent 0.010

#23

KEGG

Benzoate degradation

map00362

15 Reactions

24 Proteins

9 Chokepoints

60.0% Density

13 Connects to

Best target signal 1.063 mean 0.613

Open pathway map

VK055_0342 drug 0.91 · cent 0.016 VK055_0613 drug 0.85 · cent 0.000 VK055_0415 drug 0.68 · cent 0.602 VK055_3136 drug 0.84 · cent 0.118 VK055_1032 drug 0.80 · cent 0.062

#24

KEGG

Selenocompound metabolism

map00450

5 Reactions

8 Proteins

3 Chokepoints

60.0% Density

3 Connects to

Best target signal 1.045 mean 0.57

Open pathway map

VK055_3151 drug 0.89 · cent 0.010 VK055_4046 drug 0.67 · cent 0.011 VK055_4402 drug 0.63 · cent 0.010 VK055_0773 drug 0.54 · cent 0.011 VK055_4065 drug 0.52 · cent 0.011

#25

KEGG

Fructose and mannose metabolism

map00051

15 Reactions

18 Proteins

9 Chokepoints

60.0% Density

12 Connects to

Best target signal 0.98 mean 0.557

Open pathway map

VK055_2206 drug 0.95 · cent 0.336 VK055_1343 drug 0.87 · cent 0.304 VK055_4360 drug 0.70 · cent 0.187 VK055_4863 drug 0.70 · cent 0.046 VK055_3463 drug 0.77 · cent 0.304

#26

KEGG

Phenylalanine metabolism

map00360

14 Reactions

18 Proteins

8 Chokepoints

57.1% Density

15 Connects to

Best target signal 1.136 mean 0.759

Open pathway map

VK055_0339 drug 0.99 · cent 0.000 VK055_0340 drug 0.96 · cent 0.015 VK055_2005 drug 0.95 · cent 0.051 VK055_0342 drug 0.91 · cent 0.016 VK055_1046 drug 0.89 · cent 0.051

#27

KEGG

Lipoic acid metabolism

map00785

7 Reactions

10 Proteins

4 Chokepoints

57.1% Density

1 Connects to

Best target signal 0.991 mean 0.796

Open pathway map

VK055_2451 drug 0.84 · cent 0.010 VK055_2294 drug 0.82 · cent 0.021 VK055_4144 drug 0.96 · cent 0.043 VK055_4142 drug 0.94 · cent 0.169 VK055_5062 drug 0.93 · cent 0.025

#28

KEGG

Tyrosine metabolism

map00350

7 Reactions

8 Proteins

4 Chokepoints

57.1% Density

8 Connects to

Best target signal 0.929 mean 0.737

Open pathway map

VK055_3030 drug 0.92 · cent 0.139 VK055_2650 drug 0.88 · cent 0.031 VK055_2653 drug 0.71 · cent 0.036 VK055_2651 drug 0.85 · cent 0.031 VK055_2652 drug 0.70 · cent 0.036

#29

KEGG

Pantothenate and CoA biosynthesis

map00770

13 Reactions

19 Proteins

7 Chokepoints

53.8% Density

9 Connects to

Best target signal 1.151 mean 0.661

Open pathway map

VK055_3208 drug 1.00 · cent 0.031 VK055_3391 drug 1.00 · cent 0.031 VK055_2490 drug 0.96 · cent 0.031 VK055_0407 drug 0.96 · cent 0.031 VK055_3122 drug 0.84 · cent 0.046

#30

KEGG

Histidine metabolism

map00340

13 Reactions

15 Proteins

7 Chokepoints

53.8% Density

8 Connects to

Best target signal 1.124 mean 0.728

Open pathway map

VK055_5040 drug 0.97 · cent 0.062 VK055_5039 drug 1.00 · cent 0.079 VK055_1736 drug 0.83 · cent 0.031 VK055_0315 drug 0.94 · cent 0.000 VK055_5044 drug 0.87 · cent 0.051

#31

KEGG

Arginine and proline metabolism

map00330

17 Reactions

24 Proteins

9 Chokepoints

52.9% Density

9 Connects to

Best target signal 1.106 mean 0.596

Open pathway map

VK055_2442 drug 0.95 · cent 0.052 VK055_1236 drug 0.92 · cent 0.016 VK055_1235 drug 0.90 · cent 0.026 VK055_1436 drug 0.96 · cent 0.000 VK055_1012 drug 0.75 · cent 0.026

#32

KEGG

C5-Branched dibasic acid metabolism

map00660

2 Reactions

6 Proteins

1 Chokepoints

50.0% Density

0 Connects to

Best target signal 1.151 mean 0.948

Open pathway map

VK055_3208 drug 1.00 · cent 0.031 VK055_3391 drug 1.00 · cent 0.031 VK055_2490 drug 0.96 · cent 0.031 VK055_0407 drug 0.96 · cent 0.031 VK055_2489 drug 0.71 · cent 0.031

#33

KEGG

Glutathione metabolism

map00480

8 Reactions

8 Proteins

4 Chokepoints

50.0% Density

5 Connects to

Best target signal 1.124 mean 0.716

Open pathway map

VK055_4099 drug 0.97 · cent 0.000 VK055_2442 drug 0.95 · cent 0.052 VK055_0081 drug 0.70 · cent 0.000 VK055_4497 drug 0.59 · cent 0.000 VK055_5026 drug 0.69 · cent 0.031

#34

KEGG

Biosynthesis of various plant secondary metabolites

map00999

2 Reactions

3 Proteins

1 Chokepoints

50.0% Density

0 Connects to

Best target signal 1.105 mean 0.86

Open pathway map

VK055_1196 drug 0.95 · cent 0.104 VK055_1197 drug 0.93 · cent 0.104 VK055_4104 drug 0.39 · cent 0.000

#35

KEGG

D-Amino acid metabolism

map00470

8 Reactions

14 Proteins

4 Chokepoints

50.0% Density

3 Connects to

Best target signal 0.925 mean 0.578

Open pathway map

VK055_1997 drug 0.93 · cent 0.000 VK055_4093 drug 0.87 · cent 0.000 VK055_4272 drug 0.78 · cent 0.000 VK055_2233 drug 0.63 · cent 0.034 VK055_3220 drug 0.59 · cent 0.000

#36

KEGG

Riboflavin metabolism

map00740

10 Reactions

10 Proteins

5 Chokepoints

50.0% Density

4 Connects to

Best target signal 0.867 mean 0.592

Open pathway map

VK055_1607 drug 0.86 · cent 0.093 VK055_2187 drug 0.68 · cent 0.108 VK055_1178 drug 0.65 · cent 0.024 VK055_1514 drug 0.70 · cent 0.093 VK055_3137 drug 0.65 · cent 0.093

#37

KEGG

Vitamin B6 metabolism

map00750

8 Reactions

6 Proteins

4 Chokepoints

50.0% Density

3 Connects to

Best target signal 0.852 mean 0.609

Open pathway map

VK055_4126 drug 0.70 · cent 0.015 VK055_0503 drug 0.70 · cent 0.000 VK055_0501 drug 0.55 · cent 0.000 VK055_1549 drug 0.70 · cent 0.024 VK055_4612 drug 0.22 · cent 0.005

#38

KEGG

Porphyrin metabolism

map00860

28 Reactions

26 Proteins

13 Chokepoints

46.4% Density

4 Connects to

Best target signal 0.939 mean 0.615

Open pathway map

VK055_4342 drug 0.79 · cent 0.011 VK055_4401 drug 0.75 · cent 0.000 VK055_2396 drug 0.72 · cent 0.010 VK055_4327 drug 0.87 · cent 0.012 VK055_2164 drug 0.86 · cent 0.000

#39

KEGG

Pentose and glucuronate interconversions

map00040

18 Reactions

22 Proteins

8 Chokepoints

44.4% Density

10 Connects to

Best target signal 0.981 mean 0.578

Open pathway map

VK055_2512 drug 0.82 · cent 0.133 VK055_4916 drug 0.76 · cent 0.021 VK055_2872 drug 0.83 · cent 0.153 VK055_3857 drug 0.66 · cent 0.026 VK055_2874 drug 0.66 · cent 0.005

#40

KEGG

Pyrimidine metabolism

map00240

37 Reactions

27 Proteins

15 Chokepoints

40.5% Density

23 Connects to

Best target signal 1.141 mean 0.632

Open pathway map

VK055_1513 drug 0.98 · cent 0.096 VK055_4389 drug 0.93 · cent 0.011 VK055_2593 drug 0.84 · cent 0.010 VK055_2808 drug 0.79 · cent 0.008 VK055_2533 drug 0.92 · cent 0.046

#41

KEGG

Lysine biosynthesis

map00300

10 Reactions

13 Proteins

4 Chokepoints

40.0% Density

9 Connects to

Best target signal 0.895 mean 0.615

Open pathway map

VK055_2483 drug 0.74 · cent 0.025 VK055_0716 drug 0.84 · cent 0.090 VK055_2572 drug 0.73 · cent 0.089 VK055_4699 drug 0.57 · cent 0.016 VK055_0774 drug 0.71 · cent 0.000

#42

KEGG

Cysteine and methionine metabolism

map00270

28 Reactions

29 Proteins

11 Chokepoints

39.3% Density

15 Connects to

Best target signal 1.106 mean 0.697

Open pathway map

VK055_2442 drug 0.95 · cent 0.052 VK055_1889 drug 0.83 · cent 0.005 VK055_3030 drug 0.92 · cent 0.139 VK055_1890 drug 0.91 · cent 0.015 VK055_4743 drug 0.90 · cent 0.064

#43

KEGG

Galactose metabolism

map00052

13 Reactions

14 Proteins

5 Chokepoints

38.5% Density

8 Connects to

Best target signal 1.094 mean 0.584

Open pathway map

VK055_3367 drug 0.94 · cent 0.005 VK055_5034 drug 0.90 · cent 0.000 VK055_1764 drug 0.87 · cent 0.020 VK055_1820 drug 0.86 · cent 0.000 VK055_3369 drug 0.60 · cent 0.000

#44

KEGG

Lipopolysaccharide biosynthesis

map00540

8 Reactions

8 Proteins

3 Chokepoints

37.5% Density

7 Connects to

Best target signal 1.012 mean 0.812

Open pathway map

VK055_0077 drug 0.86 · cent 0.020 VK055_2067 drug 0.99 · cent 0.000 VK055_2370 drug 0.92 · cent 0.030 VK055_2471 drug 0.90 · cent 0.005 VK055_2373 drug 0.71 · cent 0.031

#45

KEGG

Ascorbate and aldarate metabolism

map00053

8 Reactions

10 Proteins

3 Chokepoints

37.5% Density

3 Connects to

Best target signal 0.944 mean 0.643

Open pathway map

VK055_4383 drug 0.94 · cent 0.000 VK055_2872 drug 0.83 · cent 0.153 VK055_3926 drug 0.83 · cent 0.000 VK055_2874 drug 0.66 · cent 0.005 VK055_2878 drug 0.63 · cent 0.000

#46

KEGG

Valine, leucine and isoleucine biosynthesis

map00290

14 Reactions

15 Proteins

5 Chokepoints

35.7% Density

7 Connects to

Best target signal 1.151 mean 0.662

Open pathway map

VK055_3391 drug 1.00 · cent 0.031 VK055_3208 drug 1.00 · cent 0.031 VK055_2490 drug 0.96 · cent 0.031 VK055_0407 drug 0.96 · cent 0.031 VK055_4376 drug 0.90 · cent 0.031

#47

KEGG

Arginine biosynthesis

map00220

14 Reactions

23 Proteins

5 Chokepoints

35.7% Density

17 Connects to

Best target signal 1.069 mean 0.642

Open pathway map

VK055_4299 drug 0.92 · cent 0.000 VK055_5039 drug 1.00 · cent 0.079 VK055_1836 drug 1.00 · cent 0.020 VK055_3030 drug 0.92 · cent 0.139 VK055_2533 drug 0.92 · cent 0.046

#48

KEGG

Alanine, aspartate and glutamate metabolism

map00250

18 Reactions

30 Proteins

6 Chokepoints

33.3% Density

18 Connects to

Best target signal 1.192 mean 0.617

Open pathway map

VK055_2887 drug 0.98 · cent 0.670 VK055_5039 drug 1.00 · cent 0.079 VK055_3341 drug 0.99 · cent 0.097 VK055_1836 drug 1.00 · cent 0.020 VK055_2808 drug 0.79 · cent 0.008

#49

KEGG

Nicotinate and nicotinamide metabolism

map00760

12 Reactions

12 Proteins

4 Chokepoints

33.3% Density

11 Connects to

Best target signal 1.141 mean 0.622

Open pathway map

VK055_1520 drug 0.99 · cent 0.042 VK055_1772 drug 0.87 · cent 0.053 VK055_2586 drug 0.96 · cent 0.000 VK055_1230 drug 0.69 · cent 0.000 VK055_1258 drug 0.65 · cent 0.000

#50

KEGG

Sulfur metabolism

map00920

9 Reactions

12 Proteins

3 Chokepoints

33.3% Density

5 Connects to

Best target signal 1.086 mean 0.693

Open pathway map

VK055_4404 drug 0.93 · cent 0.015 VK055_4399 drug 0.80 · cent 0.041 VK055_4398 drug 0.92 · cent 0.077 VK055_4743 drug 0.90 · cent 0.064 VK055_3243 drug 0.84 · cent 0.488

#51

KEGG

Dioxin degradation

map00621

3 Reactions

3 Proteins

1 Chokepoints

33.3% Density

0 Connects to

Best target signal 1.063 mean 0.609

Open pathway map

VK055_0342 drug 0.91 · cent 0.016 VK055_0343 drug 0.73 · cent 0.010 VK055_0344 drug 0.03 · cent 0.021

#52

KEGG

Amino sugar and nucleotide sugar metabolism

map00520

24 Reactions

26 Proteins

8 Chokepoints

33.3% Density

12 Connects to

Best target signal 0.999 mean 0.52

Open pathway map

VK055_3341 drug 0.99 · cent 0.097 VK055_5034 drug 0.90 · cent 0.000 VK055_1361 drug 0.74 · cent 0.002 VK055_1347 drug 0.87 · cent 0.022 VK055_1764 drug 0.87 · cent 0.020

#53

KEGG

Mycolic acid biosynthesis

map00074

3 Reactions

7 Proteins

1 Chokepoints

33.3% Density

1 Connects to

Best target signal 0.982 mean 0.565

Open pathway map

VK055_2367 drug 0.97 · cent 0.142 VK055_1375 drug 0.66 · cent 0.375 VK055_3811 drug 0.56 · cent 0.142 VK055_3812 drug 0.55 · cent 0.142 VK055_4807 drug 0.53 · cent 0.142

#54

KEGG

Fatty acid biosynthesis

map00061

3 Reactions

6 Proteins

1 Chokepoints

33.3% Density

5 Connects to

Best target signal 0.982 mean 0.623

Open pathway map

VK055_2367 drug 0.97 · cent 0.142 VK055_1375 drug 0.66 · cent 0.375 VK055_3811 drug 0.56 · cent 0.142 VK055_3812 drug 0.55 · cent 0.142 VK055_4807 drug 0.53 · cent 0.142

#55

KEGG

Carbapenem biosynthesis

map00332

3 Reactions

3 Proteins

1 Chokepoints

33.3% Density

3 Connects to

Best target signal 0.923 mean 0.512

Open pathway map

VK055_2533 drug 0.92 · cent 0.046 VK055_2280 drug 0.29 · cent 0.000 VK055_2281 drug 0.17 · cent 0.005

#56

KEGG

Phosphonate and phosphinate metabolism

map00440

3 Reactions

5 Proteins

1 Chokepoints

33.3% Density

6 Connects to

Best target signal 0.819 mean 0.57

Open pathway map

VK055_2968 drug 0.67 · cent 0.005 VK055_2967 drug 0.64 · cent 0.005 VK055_3400 drug 0.52 · cent 0.005 VK055_3402 drug 0.38 · cent 0.000 VK055_2972 drug 0.19 · cent 0.005

#57

KEGG

Pentose phosphate pathway

map00030

20 Reactions

30 Proteins

6 Chokepoints

30.0% Density

17 Connects to

Best target signal 1.062 mean 0.609

Open pathway map

VK055_2594 drug 0.91 · cent 0.061 VK055_1755 drug 0.90 · cent 0.015 VK055_0391 drug 0.98 · cent 0.137 VK055_0392 drug 0.97 · cent 0.137 VK055_2206 drug 0.95 · cent 0.336

#58

KEGG

Citrate cycle (TCA cycle)

map00020

14 Reactions

24 Proteins

4 Chokepoints

28.6% Density

18 Connects to

Best target signal 1.009 mean 0.698

Open pathway map

VK055_0948 drug 1.00 · cent 0.097 VK055_2451 drug 0.84 · cent 0.010 VK055_2294 drug 0.82 · cent 0.021 VK055_1056 drug 0.96 · cent 0.000 VK055_4892 drug 0.95 · cent 0.097

#59

KEGG

Purine metabolism

map00230

62 Reactions

42 Proteins

15 Chokepoints

24.2% Density

18 Connects to

Best target signal 1.192 mean 0.623

Open pathway map

VK055_2887 drug 0.98 · cent 0.670 VK055_2093 drug 0.97 · cent 0.002 VK055_4404 drug 0.93 · cent 0.015 VK055_4619 drug 0.90 · cent 0.011 VK055_2098 drug 0.92 · cent 0.245

#60

KEGG

Propanoate metabolism

map00640

9 Reactions

17 Proteins

2 Chokepoints

22.2% Density

14 Connects to

Best target signal 0.982 mean 0.63

Open pathway map

VK055_2367 drug 0.97 · cent 0.142 VK055_4319 drug 0.75 · cent 0.000 VK055_1793 drug 0.87 · cent 0.053 VK055_4303 drug 0.86 · cent 0.005 VK055_1794 drug 0.80 · cent 0.053

#61

KEGG

Xylene degradation

map00622

5 Reactions

4 Proteins

1 Chokepoints

20.0% Density

0 Connects to

Best target signal 1.063 mean 0.68

Open pathway map

VK055_0342 drug 0.91 · cent 0.016 VK055_0533 drug 0.89 · cent 0.000 VK055_0343 drug 0.73 · cent 0.010 VK055_0344 drug 0.03 · cent 0.021

#62

KEGG

Taurine and hypotaurine metabolism

map00430

5 Reactions

9 Proteins

1 Chokepoints

20.0% Density

5 Connects to

Best target signal 0.858 mean 0.597

Open pathway map

VK055_0348 drug 0.71 · cent 0.000 VK055_4303 drug 0.86 · cent 0.005 VK055_4714 drug 0.81 · cent 0.000 VK055_4827 drug 0.77 · cent 0.000 VK055_2242 drug 0.69 · cent 0.000

#63

KEGG

Glycine, serine and threonine metabolism

map00260

27 Reactions

35 Proteins

5 Chokepoints

18.5% Density

26 Connects to

Best target signal 1.151 mean 0.664

Open pathway map

VK055_1395 drug 1.00 · cent 0.005 VK055_1043 drug 0.99 · cent 0.025 VK055_2570 drug 0.85 · cent 0.025 VK055_4385 drug 0.97 · cent 0.047 VK055_4144 drug 0.96 · cent 0.043

#64

KEGG

Butanoate metabolism

map00650

11 Reactions

20 Proteins

2 Chokepoints

18.2% Density

7 Connects to

Best target signal 1.151 mean 0.698

Open pathway map

VK055_3208 drug 1.00 · cent 0.031 VK055_3391 drug 1.00 · cent 0.031 VK055_2490 drug 0.96 · cent 0.031 VK055_0407 drug 0.96 · cent 0.031 VK055_1056 drug 0.96 · cent 0.000

#65

KEGG

Glycerophospholipid metabolism

map00564

12 Reactions

13 Proteins

2 Chokepoints

16.7% Density

12 Connects to

Best target signal 1.006 mean 0.666

Open pathway map

VK055_3518 drug 0.97 · cent 0.352 VK055_1714 drug 0.95 · cent 0.108 VK055_2908 drug 0.80 · cent 0.028 VK055_4038 drug 0.90 · cent 0.284 VK055_3044 drug 0.79 · cent 0.137

#66

KEGG

Glycolysis / Gluconeogenesis

map00010

18 Reactions

26 Proteins

3 Chokepoints

16.7% Density

25 Connects to

Best target signal 0.991 mean 0.61

Open pathway map

VK055_2451 drug 0.84 · cent 0.010 VK055_2206 drug 0.95 · cent 0.336 VK055_2294 drug 0.82 · cent 0.021 VK055_1056 drug 0.96 · cent 0.000 VK055_4152 drug 0.95 · cent 0.000

#67

KEGG

Valine, leucine and isoleucine degradation

map00280

6 Reactions

7 Proteins

1 Chokepoints

16.7% Density

23 Connects to

Best target signal 0.855 mean 0.675

Open pathway map

VK055_3136 drug 0.84 · cent 0.118 VK055_3206 drug 0.68 · cent 0.026 VK055_4789 drug 0.76 · cent 0.118 VK055_0415 drug 0.68 · cent 0.602 VK055_2788 drug 0.54 · cent 0.321

#68

KEGG

Pyruvate metabolism

map00620

25 Reactions

52 Proteins

4 Chokepoints

16.0% Density

11 Connects to

Best target signal 1.009 mean 0.618

Open pathway map

VK055_0948 drug 1.00 · cent 0.097 VK055_4953 drug 1.00 · cent 0.000 VK055_2451 drug 0.84 · cent 0.010 VK055_2367 drug 0.97 · cent 0.142 VK055_2294 drug 0.82 · cent 0.021

#69

KEGG

One carbon pool by folate

map00670

14 Reactions

14 Proteins

2 Chokepoints

14.3% Density

7 Connects to

Best target signal 0.99 mean 0.572

Open pathway map

VK055_4136 drug 0.99 · cent 0.000 VK055_4142 drug 0.94 · cent 0.169 VK055_3086 drug 0.71 · cent 0.452 VK055_1953 drug 0.88 · cent 0.000 VK055_1952 drug 0.69 · cent 0.000

#70

KEGG

Starch and sucrose metabolism

map00500

7 Reactions

14 Proteins

1 Chokepoints

14.3% Density

7 Connects to

Best target signal 0.983 mean 0.589

Open pathway map

VK055_4445 drug 0.98 · cent 0.000 VK055_4152 drug 0.95 · cent 0.000 VK055_4946 drug 0.72 · cent 0.000 VK055_3380 drug 0.68 · cent 0.000 VK055_1223 drug 0.68 · cent 0.000

#71

MODEL

Unassigned metabolic reactions

unassigned

972 Reactions

542 Proteins

125 Chokepoints

12.9% Density

75 Connects to

Best target signal 1.146 mean 0.602

Open pathway map

VK055_3045 drug 0.99 · cent 0.015 VK055_2067 drug 0.99 · cent 0.000 VK055_0671 drug 0.99 · cent 0.010 VK055_4575 drug 0.99 · cent 0.005 VK055_2450 drug 0.98 · cent 0.043

#72

KEGG

Glucosinolate biosynthesis

map00966

8 Reactions

3 Proteins

1 Chokepoints

12.5% Density

1 Connects to

Best target signal 0.899 mean 0.621

Open pathway map

VK055_4376 drug 0.90 · cent 0.031 VK055_3206 drug 0.68 · cent 0.026 VK055_2494 drug 0.13 · cent 0.031

#73

KEGG

Glycerolipid metabolism

map00561

11 Reactions

19 Proteins

1 Chokepoints

9.1% Density

10 Connects to

Best target signal 1.09 mean 0.772

Open pathway map

VK055_3984 drug 0.94 · cent 0.015 VK055_3970 drug 0.99 · cent 0.021 VK055_4385 drug 0.97 · cent 0.047 VK055_3982 drug 0.80 · cent 0.015 VK055_4038 drug 0.90 · cent 0.284

#74

KEGG

Methane metabolism

map00680

19 Reactions

38 Proteins

1 Chokepoints

5.3% Density

5 Connects to

Best target signal 1.009 mean 0.71

Open pathway map

VK055_0948 drug 1.00 · cent 0.097 VK055_0372 drug 1.00 · cent 0.000 VK055_3970 drug 0.99 · cent 0.021 VK055_0617 drug 0.99 · cent 0.000 VK055_0619 drug 0.99 · cent 0.000

#75

KEGG

Aminoacyl-tRNA biosynthesis

map00970

22 Reactions

25 Proteins

1 Chokepoints

4.5% Density

15 Connects to

Best target signal 0.973 mean 0.576

Open pathway map

VK055_1526 drug 0.97 · cent 0.000 VK055_1560 drug 0.95 · cent 0.005 VK055_2554 drug 0.94 · cent 0.000 VK055_1830 drug 0.93 · cent 0.000 VK055_3547 drug 0.92 · cent 0.000

#76

KEGG

Glyoxylate and dicarboxylate metabolism

map00630

26 Reactions

40 Proteins

0 Chokepoints

0.0% Density

19 Connects to

Best target signal 1.009 mean 0.683

Open pathway map

VK055_0948 drug 1.00 · cent 0.097 VK055_0372 drug 1.00 · cent 0.000 VK055_0617 drug 0.99 · cent 0.000 VK055_0619 drug 0.99 · cent 0.000 VK055_3271 drug 0.98 · cent 0.005

#77

KEGG

Other carbon fixation pathways

map00720

17 Reactions

34 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 1.009 mean 0.645

Open pathway map

VK055_0948 drug 1.00 · cent 0.097 VK055_2367 drug 0.97 · cent 0.142 VK055_3231 drug 0.96 · cent 0.110 VK055_1056 drug 0.96 · cent 0.000 VK055_4892 drug 0.95 · cent 0.097

#78

KEGG

Carbon fixation by Calvin cycle

map00710

11 Reactions

21 Proteins

0 Chokepoints

0.0% Density

10 Connects to

Best target signal 1.009 mean 0.662

Open pathway map

VK055_0948 drug 1.00 · cent 0.097 VK055_2206 drug 0.95 · cent 0.336 VK055_3231 drug 0.96 · cent 0.110 VK055_4892 drug 0.95 · cent 0.097 VK055_3030 drug 0.92 · cent 0.139

#79

KEGG

Nitrogen metabolism

map00910

6 Reactions

11 Proteins

0 Chokepoints

0.0% Density

3 Connects to

Best target signal 0.999 mean 0.639

Open pathway map

VK055_0600 drug 1.00 · cent 0.000 VK055_0238 drug 0.98 · cent 0.000 VK055_0242 drug 0.98 · cent 0.000 VK055_2533 drug 0.92 · cent 0.046 VK055_0603 drug 0.89 · cent 0.000

#80

KEGG

Nitrogen cycle

map01310

2 Reactions

6 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.999 mean 0.79

Open pathway map

VK055_0600 drug 1.00 · cent 0.000 VK055_0238 drug 0.98 · cent 0.000 VK055_0242 drug 0.98 · cent 0.000 VK055_0603 drug 0.89 · cent 0.000 VK055_0239 drug 0.45 · cent 0.000

#81

KEGG

Tropane, piperidine and pyridine alkaloid biosynthesis

map00960

3 Reactions

4 Proteins

0 Chokepoints

0.0% Density

2 Connects to

Best target signal 0.987 mean 0.689

Open pathway map

VK055_1043 drug 0.99 · cent 0.025 VK055_3030 drug 0.92 · cent 0.139 VK055_1071 drug 0.57 · cent 0.139 VK055_2366 drug 0.25 · cent 0.055

#82

KEGG

Aflatoxin biosynthesis

map00254

1 Reactions

4 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.982 mean 0.668

Open pathway map

VK055_2367 drug 0.97 · cent 0.142 VK055_3811 drug 0.56 · cent 0.142 VK055_3812 drug 0.55 · cent 0.142 VK055_4807 drug 0.53 · cent 0.142

#83

KEGG

Tryptophan metabolism

map00380

5 Reactions

9 Proteins

0 Chokepoints

0.0% Density

4 Connects to

Best target signal 0.929 mean 0.629

Open pathway map

VK055_3030 drug 0.92 · cent 0.139 VK055_3136 drug 0.84 · cent 0.118 VK055_4789 drug 0.76 · cent 0.118 VK055_1167 drug 0.74 · cent 0.000 VK055_4773 drug 0.62 · cent 0.010

#84

KEGG

Novobiocin biosynthesis

map00401

1 Reactions

2 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.929 mean 0.758

Open pathway map

VK055_3030 drug 0.92 · cent 0.139 VK055_1071 drug 0.57 · cent 0.139

#85

KEGG

Isoquinoline alkaloid biosynthesis

map00950

1 Reactions

2 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.929 mean 0.758

Open pathway map

VK055_3030 drug 0.92 · cent 0.139 VK055_1071 drug 0.57 · cent 0.139

#86

KEGG

Caprolactam degradation

map00930

1 Reactions

3 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.919 mean 0.821

Open pathway map

VK055_3135 drug 0.91 · cent 0.093 VK055_1035 drug 0.83 · cent 0.093 VK055_4790 drug 0.70 · cent 0.093

#87

KEGG

Toluene degradation

map00623

3 Reactions

3 Proteins

0 Chokepoints

0.0% Density

1 Connects to

Best target signal 0.894 mean 0.488

Open pathway map

VK055_0533 drug 0.89 · cent 0.000 VK055_0961 drug 0.54 · cent 0.081 VK055_0609 drug 0.02 · cent 0.041

#88

KEGG

Lysine degradation

map00310

4 Reactions

6 Proteins

0 Chokepoints

0.0% Density

8 Connects to

Best target signal 0.855 mean 0.562

Open pathway map

VK055_3136 drug 0.84 · cent 0.118 VK055_4789 drug 0.76 · cent 0.118 VK055_0774 drug 0.71 · cent 0.000 VK055_4877 drug 0.47 · cent 0.118 VK055_4880 drug 0.27 · cent 0.384

#89

KEGG

Fatty acid degradation

map00071

5 Reactions

3 Proteins

0 Chokepoints

0.0% Density

5 Connects to

Best target signal 0.855 mean 0.701

Open pathway map

VK055_3136 drug 0.84 · cent 0.118 VK055_4789 drug 0.76 · cent 0.118 VK055_4877 drug 0.47 · cent 0.118

#90

KEGG

Fatty acid elongation

map00062

4 Reactions

3 Proteins

0 Chokepoints

0.0% Density

4 Connects to

Best target signal 0.855 mean 0.701

Open pathway map

VK055_3136 drug 0.84 · cent 0.118 VK055_4789 drug 0.76 · cent 0.118 VK055_4877 drug 0.47 · cent 0.118

#91

KEGG

Ethylbenzene degradation

map00642

1 Reactions

2 Proteins

0 Chokepoints

0.0% Density

1 Connects to

Best target signal 0.855 mean 0.813

Open pathway map

VK055_3136 drug 0.84 · cent 0.118 VK055_4789 drug 0.76 · cent 0.118

#92

KEGG

Phenylpropanoid biosynthesis

map00940

1 Reactions

4 Proteins

0 Chokepoints

0.0% Density

1 Connects to

Best target signal 0.834 mean 0.544

Open pathway map

VK055_3622 drug 0.83 · cent 0.000 VK055_4419 drug 0.78 · cent 0.061 VK055_4418 drug 0.55 · cent 0.061 VK055_4420 drug 0.00 · cent 0.061

#93

KEGG

Biotin metabolism

map00780

3 Reactions

4 Proteins

0 Chokepoints

0.0% Density

1 Connects to

Best target signal 0.828 mean 0.551

Open pathway map

VK055_1730 drug 0.83 · cent 0.005 VK055_1728 drug 0.76 · cent 0.015 VK055_1732 drug 0.54 · cent 0.010 VK055_0924 drug 0.08 · cent 0.015

#94

KEGG

Aminobenzoate degradation

map00627

3 Reactions

6 Proteins

0 Chokepoints

0.0% Density

4 Connects to

Best target signal 0.784 mean 0.483

Open pathway map

VK055_4419 drug 0.78 · cent 0.061 VK055_0530 drug 0.62 · cent 0.035 VK055_4418 drug 0.55 · cent 0.061 VK055_0529 drug 0.54 · cent 0.035 VK055_4879 drug 0.39 · cent 0.000

#95

KEGG

Biosynthesis of type II polyketide products

map01057

1 Reactions

3 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.705 mean 0.609

Open pathway map

VK055_1514 drug 0.70 · cent 0.093 VK055_3137 drug 0.65 · cent 0.093 VK055_1444 drug 0.45 · cent 0.093

#96

KEGG

Phenazine biosynthesis

map00405

1 Reactions

1 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.664 mean 0.664

Open pathway map

VK055_1193 drug 0.66 · cent 0.008

#97

KEGG

Neomycin, kanamycin and gentamicin biosynthesis

map00524

1 Reactions

1 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.655 mean 0.655

Open pathway map

VK055_4774 drug 0.66 · cent 0.000

#98

KEGG

Biosynthesis of various siderophores

map00975

3 Reactions

3 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.638 mean 0.491

Open pathway map

VK055_0686 drug 0.64 · cent 0.016 VK055_0687 drug 0.58 · cent 0.025 VK055_2366 drug 0.25 · cent 0.055

#99

KEGG

Cyanoamino acid metabolism

map00460

2 Reactions

2 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.448 mean 0.42

Open pathway map

VK055_4625 drug 0.42 · cent 0.298 VK055_3324 drug 0.39 · cent 0.008

#100

KEGG

Biosynthesis of various antibiotics

map00998

1 Reactions

1 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.417 mean 0.417

Open pathway map

VK055_3519 drug 0.42 · cent 0.024

#101

KEGG

Sulfoquinovose metabolism

map00566

1 Reactions

1 Proteins

0 Chokepoints

0.0% Density

0 Connects to

Best target signal 0.296 mean 0.296

Open pathway map

VK055_0250 drug 0.28 · cent 0.164

#102

KEGG

Fluorobenzoate degradation

map00364

1 Reactions

1 Proteins

0 Chokepoints

0.0% Density

2 Connects to

Best target signal 0.294 mean 0.294

Open pathway map

VK055_0611 drug 0.29 · cent 0.000

Metabolic pathways

Pathway target space