Metabolic network

VK055_0077

lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase

Back to protein
Network centrality 0.02003 top 92.3%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing & consuming chokepoint reaction in Lipopolysaccharide biosynthesis, no isoenzyme backup detected, more central than 92.3% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Lipopolysaccharide biosynthesis

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

Select a node
EC
-
Pathway
-
Genes
-
Role
-
Isoenzymes
-

Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

MYRISTOYLACYLTRAN-RXN

EC 2.3.1.243 · MYRISTOYLACYLTRAN-RXN · not reversible · no isoenzyme backup

Producing & consuming chokepoint
a myristoyl-[acp] alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(lauroyl)-lipid IVA (E. coli)
→
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A (E. coli) a soluble [acyl-carrier protein]

Imported from KpATCC43816.sbml · 2026-07-09