KEGG:map00540

Lipopolysaccharide biosynthesis

KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

All pathways Protein ranking
Reactions 10
Proteins 8
Metabolites 24
Chokepoints 3

Pathway map

Reaction-to-metabolite flow reconstructed from the imported SBML participants.

Chokepoint reaction Metabolite ⇌ Reversible reaction Currency metabolites hidden
Computing layout…

Connected pathways

Other pathways in this genome that share reactions with this one.

MODEL Unassigned metabolic reactions 15 shared KEGG Fatty acid biosynthesis 4 shared KEGG Glycerophospholipid metabolism 2 shared KEGG Pyrimidine metabolism 2 shared KEGG Biosynthesis of various nucleotide sugars 2 shared KEGG Amino sugar and nucleotide sugar metabolism 1 shared KEGG Peptidoglycan biosynthesis 1 shared

Reaction table

Catalyzed reactions, mapped genes, and SBML substrates/products.

KDOTRANS2-RXN

EC 2.4.99.13 · R05074 · KDOTRANS2-RXN · not reversible

CMP-3-deoxy-beta-D-manno-octulosonate alpha-Kdo-(2->6)-lipid IVA (E. coli)
→
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) CMP H+
No mapped protein

KDOTRANS-RXN

EC 2.4.99.12 · R04658 · KDOTRANS-RXN · not reversible

CMP-3-deoxy-beta-D-manno-octulosonate lipid IVA (E. coli)
→
alpha-Kdo-(2->6)-lipid IVA (E. coli) CMP H+
VK055_3497

LAUROYLACYLTRAN-RXN

EC 2.3.1.241 · R05146 · LAUROYLACYLTRAN-RXN · not reversible

a dodecanoyl-[acp] alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)
→
a soluble [acyl-carrier protein] alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(lauroyl)-lipid IVA (E. coli)
No mapped protein

LIPIDADISACCHARIDESYNTH-RXN

EC 2.4.1.182 · R04606 · LIPIDADISACCHARIDESYNTH-RXN · not reversible

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine lipid X (E. coli)
→
lipid A disaccharide (E. coli) H+ UDP
VK055_2370

LIPIDXSYNTHESIS-RXN

EC 3.6.1.54 · R04549 · LIPIDXSYNTHESIS-RXN · not reversible

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine H2O
→
lipid X (E. coli) H+ UMP
VK055_2067

MYRISTOYLACYLTRAN-RXN

EC 2.3.1.243 · R05075 · MYRISTOYLACYLTRAN-RXN · not reversible

both
a myristoyl-[acp] alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(lauroyl)-lipid IVA (E. coli)
→
a soluble [acyl-carrier protein] alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A (E. coli)
VK055_0077

UDPACYLGLCNACDEACETYL-RXN

EC 3.5.1.108 · R04587 · UDPACYLGLCNACDEACETYL-RXN · not reversible

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine H2O
→
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine acetate
VK055_2471

UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN

EC 2.3.1.191 · R04550 · UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN · not reversible

both
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine a (3R)-3-hydroxytetradecanoyl-[acp]
→
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine a soluble [acyl-carrier protein] H+
VK055_2373

UDPNACETYLGLUCOSAMACYLTRANS-RXN

EC 2.3.1.129 · R04567 · UDPNACETYLGLUCOSAMACYLTRANS-RXN · not reversible

producing
UDP-N-acetyl-alpha-D-glucosamine a (3R)-3-hydroxytetradecanoyl-[acp]
→
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine a soluble [acyl-carrier protein]
VK055_2371