Protein profile

VK055_0096

phosphatase 1 modulates phospho, signals proteinmisfolding

Genome: KpATCC43816

Gene: AIK78723.1 pphA Structure source: AlphaFold + ColabFold UniProt A0A0H3GRX8
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Amino acids 217
Annotations 5
Features 9
PDB binders 0
Druggability 0.272

Overview

Basic information about this protein and its source genome.

Accession
VK055_0096
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78723.1 pphA
Status
annotated
Amino acids
217
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008803 Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+. GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0110154 Cleavage of the 5'-cap of an RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.813
DEG E-value
3.03e-91
Localization
Cytoplasmic
ColabFold pLDDT
97.05

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.272
Structure A0A0H3GRX8
Pocket Pocket 12
P2Rank 0.107
Structure A0A0H3GRX8
Pocket Pocket 1
ColabFold model
FPocket 0.543 · Pocket 7
P2Rank 0.126 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008803 Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+.
  • GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
  • GO:0110154 Cleavage of the 5'-cap of an RNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 216 Gene3D G3DSA:3.60.21.10 -
1 216 InterPro IPR029052 Metallo-dependent phosphatase-like
9 213 PANTHER PTHR42850 METALLOPHOSPHOESTERASE
70 75 ProSitePatterns PS00125 Serine/threonine specific protein phosphatases signature.
70 75 InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
10 213 SUPERFAMILY SSF56300 Metallo-dependent phosphatases
10 213 InterPro IPR029052 Metallo-dependent phosphatase-like
12 142 Pfam PF00149 Calcineurin-like phosphoesterase
12 142 InterPro IPR004843 Calcineurin-like phosphoesterase domain, ApaH type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRX8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0096
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.163
2 0.106
1 0.011
11 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.59 0.107
2 1.72 0.025