Protein profile

VK055_0099

hypothetical protein

Genome: KpATCC43816

Gene: AIK78727.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H020
Export view
Amino acids 877
Annotations 1
Features 15
PDB binders 0
Druggability 0.282

Overview

Basic information about this protein and its source genome.

Accession
VK055_0099
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78727.1
Status
annotated
Amino acids
877
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
83.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.282
Structure A0A0H3H020
Pocket Pocket 47
P2Rank 0.263
Structure A0A0H3H020
Pocket Pocket 1
ColabFold model
FPocket 0.928 · Pocket 1
P2Rank 0.376 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
333 546 PANTHER PTHR30462 UNCHARACTERIZED
280 348 Pfam PF02470 MlaD protein
280 348 InterPro IPR003399 Mce/MlaD
46 137 Pfam PF02470 MlaD protein
46 137 InterPro IPR003399 Mce/MlaD
747 810 Pfam PF02470 MlaD protein
747 810 InterPro IPR003399 Mce/MlaD
636 724 Pfam PF02470 MlaD protein
636 724 InterPro IPR003399 Mce/MlaD
163 229 Pfam PF02470 MlaD protein
163 229 InterPro IPR003399 Mce/MlaD
40 877 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H020
AlphaFold — — full sequence — Viewing
ColabFold VK055_0099
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.217
20 0.109
74 0.0
75 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.3 0.263
2 1.75 0.026
3 1.52 0.018
4 1.19 0.009
5 1.0 0.005