Protein profile

VK055_0109

yebO-like family protein

Genome: KpATCC43816

Gene: AIK78737.1 Structure source: AlphaFold + ColabFold UniProt W1DK98
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Amino acids 78
Annotations 1
Features 9
PDB binders 0
Druggability 0.669

Overview

Basic information about this protein and its source genome.

Accession
VK055_0109
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78737.1
Status
annotated
Amino acids
78
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
72.973
DEG E-value
1.95e-31
Localization
Unknown
ColabFold pLDDT
74.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.669
Structure W1DK98
Pocket Pocket 1
P2Rank
Structure W1DK98
Pocket No pockets
ColabFold model
FPocket 0.416 · Pocket 8
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 68 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
2 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
18 45 Coils Coil Coil
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 78 Pfam PF13974 YebO-like protein
2 78 InterPro IPR025594 YebO-like protein
14 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
22 78 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W1DK98
AlphaFold — — full sequence — Viewing
ColabFold VK055_0109
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.669
3 0.124
2 0.01
4 0.001