Protein profile

VK055_0113

hypothetical protein

Genome: KpATCC43816

Gene: AIK78741.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H004
Export view
Amino acids 188
Annotations 2
Features 26
PDB binders 0
Druggability 0.463

Overview

Basic information about this protein and its source genome.

Accession
VK055_0113
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78741.1
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384 Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.463
Structure A0A0H3H004
Pocket Pocket 9
P2Rank 0.046
Structure A0A0H3H004
Pocket Pocket 1
ColabFold model
FPocket 0.43 · Pocket 4
P2Rank 0.052 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005384 Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
106 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 188 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
136 158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
68 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
155 165 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
31 182 Pfam PF02659 Putative manganese efflux pump
31 182 InterPro IPR003810 Putative manganese efflux pump
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 67 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
128 132 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
166 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
168 187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 185 Hamap MF_01521 Probable manganese efflux pump MntP [mntP].
1 185 InterPro IPR022929 Putative manganese efflux pump MntP
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
87 105 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 185 PANTHER PTHR35529 MANGANESE EFFLUX PUMP MNTP-RELATED
1 185 InterPro IPR003810 Putative manganese efflux pump
107 129 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
133 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H004
AlphaFold — — full sequence — Viewing
ColabFold VK055_0113
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.463
2 0.036
5 0.001
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.25 0.046