Protein profile

VK055_0189

sel1 repeat family protein

Genome: KpATCC43816

Gene: AIK78817.1 Structure source: AlphaFold + ColabFold UniProt A0A2X3G1E1
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Amino acids 355
Annotations 1
Features 18
PDB binders 0
Druggability 0.358

Overview

Basic information about this protein and its source genome.

Accession
VK055_0189
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78817.1
Status
annotated
Amino acids
355
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
89.35

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.358
Structure A0A2X3G1E1
Pocket Pocket 16
P2Rank 0.054
Structure A0A2X3G1E1
Pocket Pocket 1
ColabFold model
FPocket 0.025 · Pocket 21
P2Rank 0.052 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
201 230 SMART SM00671 sel1
201 230 InterPro IPR006597 Sel1-like repeat
129 165 SMART SM00671 sel1
129 165 InterPro IPR006597 Sel1-like repeat
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
310 355 MobiDBLite mobidb-lite consensus disorder prediction
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
21 355 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
233 340 Pfam PF19933 Domain of unknown function (DUF6396)
233 340 InterPro IPR045653 Domain of unknown function DUF6396
1 18 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
50 278 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
50 278 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
336 355 MobiDBLite mobidb-lite consensus disorder prediction
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
82 240 SUPERFAMILY SSF81901 HCP-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2X3G1E1
AlphaFold — — full sequence — Viewing
ColabFold VK055_0189
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.039
2 0.034
3 0.001
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.45 0.054
2 1.75 0.026
3 1.48 0.017
4 1.23 0.01