Protein profile

VK055_0199

type VI secretion system protein DUF879

Genome: KpATCC43816

Gene: impG2 AIK78827.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUE8
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Amino acids 587
Annotations 0
Features 8
PDB binders 0
Druggability 0.671

Overview

Basic information about this protein and its source genome.

Accession
VK055_0199
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
impG2 AIK78827.1
Status
annotated
Amino acids
587
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
27.663
Localization
Cytoplasmic
ColabFold pLDDT
84.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.671
Structure A0A0H3GUE8
Pocket Pocket 42
P2Rank 0.623
Structure A0A0H3GUE8
Pocket Pocket 1
ColabFold model
FPocket 0.591 · Pocket 41
P2Rank 0.498 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 585 PIRSF PIRSF028304 UCP028304
1 585 InterPro IPR010272 Type VI secretion system TssF
1 582 Pfam PF05947 Type VI secretion system, TssF
1 582 InterPro IPR010272 Type VI secretion system TssF
6 581 NCBIfam TIGR03359 type VI secretion system baseplate subunit TssF
6 581 InterPro IPR010272 Type VI secretion system TssF
1 584 PANTHER PTHR35370 CYTOPLASMIC PROTEIN-RELATED-RELATED
1 584 InterPro IPR010272 Type VI secretion system TssF

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUE8
AlphaFold — — full sequence — Viewing
ColabFold VK055_0199
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
25 0.001
44 0.0
47 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.99 0.623
2 7.22 0.315
3 4.78 0.174
4 3.77 0.117
5 3.25 0.09