Protein profile

VK055_0200

type VI secretion system protein DUF1305

Genome: KpATCC43816

Gene: AIK78828.1 impH2 Structure source: AlphaFold + ColabFold UniProt A0A0H3GV32
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Amino acids 363
Annotations 0
Features 5
PDB binders 0
Druggability 0.74

Overview

Basic information about this protein and its source genome.

Accession
VK055_0200
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK78828.1 impH2
Status
annotated
Amino acids
363
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.25
Localization
Cytoplasmic
ColabFold pLDDT
86.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.74
Structure A0A0H3GV32
Pocket Pocket 8
P2Rank 0.031
Structure A0A0H3GV32
Pocket Pocket 1
ColabFold model
FPocket 0.718 · Pocket 10
P2Rank 0.061 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 52 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
5 335 PANTHER PTHR35564 -
5 335 InterPro IPR010732 Type VI secretion, TssG-like
25 323 Pfam PF06996 Type VI secretion, TssG
25 323 InterPro IPR010732 Type VI secretion, TssG-like
25 323 NCBIfam TIGR03347 type VI secretion system baseplate subunit TssG

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GV32
AlphaFold — — full sequence — Viewing
ColabFold VK055_0200
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.74

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.87 0.003